Use of hematopoietic cell transplants to achieve tolerance in patients with solid organ transplants

被引：29
|
作者：
Strober, Samuel [1 ]
机构：
[1] Stanford Univ, Sch Med, Dept Med, Stanford, CA 94305 USA
来源：
BLOOD | 2016年 / 127卷 / 12期
基金：
美国国家卫生研究院;
关键词：
TOTAL LYMPHOID IRRADIATION; VERSUS-HOST-DISEASE; BONE-MARROW-TRANSPLANTATION; KILLER T-CELLS; MIXED LEUKOCYTE REACTION; LIVING DONOR KIDNEY; LONG-TERM SURVIVAL; SUPPRESSOR-CELLS; IMMUNE TOLERANCE; MAINTENANCE IMMUNOSUPPRESSION;
D O I：
10.1182/blood-2015-12-685107
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The goals of tolerance in patients with solid organ transplants are to eliminate the lifelong need for immunosuppressive (IS) drugs and to prevent graft loss due to rejection or drug toxicity. Tolerance with complete withdrawal of IS drugs has been achieved in recipients of HLA-matched and mismatched living donor kidney transplants in 3 medical centers using hematopoietic cell transplants to establish mixed or complete chimerism.
引用
收藏
页码：1539 / 1543
页数：5
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