Electrospun PLGA/collagen nanofibrous membrane as early-stage wound dressing

被引：196

作者：

Liu, Shih-Jung ^{[1
]}

Kau, Yi-Chuan ^{[1
,2
]}

Chou, Chi-Yin ^{[1
]}

Chen, Jan-Kan ^{[3
]}

Wu, Ren-Chin ^{[4
]}

Yeh, Wen-Ling ^{[5
]}

机构：

[1] Chang Gung Univ, Dept Mech Engn, Tao Yuan, Taiwan

[2] Chang Gung Mem Hosp, Dept Anesthesiol, Tao Yuan, Taiwan

[3] Chang Gung Univ, Dept Physiol & Pharmacol, Tao Yuan, Taiwan

[4] Chang Gung Mem Hosp, Dept Pathol, Tao Yuan, Taiwan

[5] Chang Gung Mem Hosp, Dept Orthoped Surg, Tao Yuan, Taiwan

来源：

JOURNAL OF MEMBRANE SCIENCE | 2010年 / 355卷 / 1-2期

关键词：

Electrospinning; Nanofibrous membranes; Polylactide-polyglycolide (PLGA); Collagen; Cell behavior; NORMAL HUMAN KERATINOCYTES; COLLAGEN NANOFIBERS; CELLULAR-RESPONSE; TISSUE; SKIN; FIBROBLASTS; DEGRADATION; SCAFFOLDS; POLYMERS; BEHAVIOR;

D O I：

10.1016/j.memsci.2010.03.012

中图分类号：

TQ [化学工业];

学科分类号：

0817 ;

摘要：

Electrospinning of polylactide-polyglycolide (PLGA)/collagen in 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP) to fabricate a biomimetic nanofibrous extracellular membranes for wound dressing and tissue engineering was investigated. The morphology of as-spun PLGA/collagen nanofibers was examined by scanning electron microscopy. The average diameter of electrospun nanofibers was 250 nm (range of 150-650 nm). Degradation rate of PLGA/collagen nanofibrous membranes, cytocompatibility and cellular responses to membranes, cell and nanofibers interactions, and open wound healing in rats were studied. It was found that nanofibrous membranes made of PLGA/collagen were functionally active in responses in human fibroblasts, and were very effective as wound-healing accelerators in early-stage wound healing. The empirical results in this study indicate that electrospun PLGA/collagen nanofibers may be a good candidate as a wound dressing for skin regeneration. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：53 / 59

页数：7

共 22 条

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