Manzamine alkalodis: isolation, cytotoxicity, antimalarial activity and SAR studies

被引：57

作者：

Ashok, Penta ^{[1
]}

Ganguly, Swastika ^{[2
]}

Murugesan, Sankaranarayanan ^{[1
]}

机构：

[1] Birla Inst Technol & Sci, Dept Pharm, Med Chem Res Lab, Pilani 333031, Rajasthan, India

[2] Birla Inst Technol, Dept Pharmaceut Sci, Mesra 835215, India

来源：

DRUG DISCOVERY TODAY | 2014年 / 19卷 / 11期

关键词：

PLAUSIBLE BIOGENETIC PRECURSORS; MARINE SPONGE; BIOLOGICAL EVALUATION; IRCINAL-A;

D O I：

10.1016/j.drudis.2014.06.010

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The infectious disease Malaria is caused by different species of the genus Plasmodium. Resistance to quinoline antimalarial drugs and decreased susceptibility to artemisinin-based combination therapy have increased the need for novel antimalarial agents. Historically, natural products have been used for the treatment of infectious diseases. Identification of natural products and their semi-synthetic derivatives with potent antimalarial activity is an important method for developing novel antimalarial agents. Manzamine alkaloids are a unique group of beta-carboline alkaloids isolated from various species of marine sponge displaying potent antimalarial activity against drug-sensitive and -resistant strains of Plasmodium. In this review, we demonstrate antimalarial potency, cytotoxicity and antimalarial SAR of manzamine alkaloids.

引用

页码：1781 / 1791

页数：11

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