Manzamine alkalodis: isolation, cytotoxicity, antimalarial activity and SAR studies

被引：57
作者：
Ashok, Penta [1 ]
Ganguly, Swastika [2 ]
Murugesan, Sankaranarayanan [1 ]
机构：
[1] Birla Inst Technol & Sci, Dept Pharm, Med Chem Res Lab, Pilani 333031, Rajasthan, India
[2] Birla Inst Technol, Dept Pharmaceut Sci, Mesra 835215, India
来源：
DRUG DISCOVERY TODAY | 2014年 / 19卷 / 11期
关键词：
PLAUSIBLE BIOGENETIC PRECURSORS; MARINE SPONGE; BIOLOGICAL EVALUATION; IRCINAL-A;
D O I：
10.1016/j.drudis.2014.06.010
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The infectious disease Malaria is caused by different species of the genus Plasmodium. Resistance to quinoline antimalarial drugs and decreased susceptibility to artemisinin-based combination therapy have increased the need for novel antimalarial agents. Historically, natural products have been used for the treatment of infectious diseases. Identification of natural products and their semi-synthetic derivatives with potent antimalarial activity is an important method for developing novel antimalarial agents. Manzamine alkaloids are a unique group of beta-carboline alkaloids isolated from various species of marine sponge displaying potent antimalarial activity against drug-sensitive and -resistant strains of Plasmodium. In this review, we demonstrate antimalarial potency, cytotoxicity and antimalarial SAR of manzamine alkaloids.
引用
收藏
页码：1781 / 1791
页数：11
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