Hereditary spastic paraplegia

被引:201
|
作者
Fink, John K.
机构
[1] Univ Michigan, Dept Neurol, Ann Arbor, MI 48109 USA
[2] Ann Arbor VA Med Ctr, Ctr Geriatr Res Educ & Clin, Ann Arbor, MI 48109 USA
关键词
D O I
10.1007/s11910-996-0011-1
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The hereditary spastic paraplegias (HSPs) comprise a large group of inherited neurologic disorders. HSP is classified according to the mode of inheritance, the HSP focus when known, and whether the spastic paraplegia syndrome occurs alone or is accompanied by additional neurologic or systemic abnormalities. Analysis of 11 recently discovered HSP genes provides insight into HSP pathogenesis. Hereditary spastic paraplegia is a clinical diagnosis for which laboratory confirmation is sometimes possible, and careful exclusion of alternate and co-existing disorders is an important element in HSP diagnosis. Treatment for HSP is presently limited to symptomatic reduction of muscle spasticity, reduction in urinary urgency, and strength and gait improvement through physical therapy. Prenatal genetic testing in HSP is possible for some individuals with the increasing availability of HSP gene analysis.
引用
收藏
页码:65 / 76
页数:12
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