MICROWAVE-ASSISTED SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF SOME PYRAZOL-1-YLQUINOXALIN-2(1H)-ONE DERIVATIVES

被引：22

作者：

Ajani, Olayinka O. ^{[1
]}

Obafemi, Craig A. ^{[2
]}

Ikpo, Chinwe O. ^{[1
]}

Ogunniran, Kehinde O. ^{[1
]}

Nwinyi, Obinna C. ^{[3
]}

机构：

[1] Covenant Univ, Coll Sci & Technol, Dept Chem, Ota, Ogun State, Nigeria

[2] Obafemi Awolowo Univ, Fac Sci, Dept Chem, Ife, Osun State, Nigeria

[3] Covenant Univ, Coll Sci & Technol, Dept Biol Sci, Ota, Ogun State, Nigeria

来源：

CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2009年 / 45卷 / 11期

关键词：

3-hydrazinoquinoxalin-2(1H)-one; imines; Gram-positive bacteria; ANTIMICROBIAL ACTIVITY; QUINOXALINES;

D O I：

10.1007/s10593-010-0435-z

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

3-Hydrazinoquinoxalin-2(1H)-one was prepared from quinoxaline-2,3-dione and subsequently used for the synthesis of some potentially biologically active 3-(pyrazol-1-yl)quinoxalin-2(1H)-one derivatives. While 3-(3,5-dimethylpyrazol-1-yl)quinoxalin-2(1H)-one showed a comparative effect with streptomycin, 3-(5-oxo-3-phenyl-4,5-di- hydropyrazol-1-yl)quinoxalin-2(1H)-one was found to be the most active with an MIC value of 7.8 mu g/ml.

引用

页码：1370 / 1378

页数：9

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