Intracortically distributed neurovascular coupling relationships within and between human somatosensory cortices

被引:20
作者
Arthurs, O. J.
Donovan, T.
Spiegelhalter, D. J.
Pickard, J. D.
Boniface, S. J.
机构
[1] Univ Cambridge, Addenbrookes Hosp, Wolfson Brain Imaging Ctr, Cambridge CB2 2QQ, England
[2] Addenbrookes Hosp, Inst Publ Hlth, MRC, Biostat Unit, Cambridge CB2 2QQ, England
基金
英国医学研究理事会;
关键词
fMRI; intracortical; neurovascular coupling; SEP;
D O I
10.1093/cercor/bhk014
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The coupling of neuronal cellular activity to its blood supply is of critical importance to the physiology of the human brain and has been under discussion for more than a century. Linearity in this relationship has been demonstrated in some animal studies, but evidence is lacking in humans. In this study, we compared scalp evoked potentials and the functional magnetic resonance imaging (fMRI) blood oxygen level-dependent (BOLD) signal from healthy human volunteers with changes in the intensity of a somatosensory stimulus. By weighting the fMRI images according to the evoked potential amplitude at corresponding intensities, we tested for positive and negative covariation between these 2 data sets and the extent to which these were linear. Hemodynamic changes in primary somatosensory cortex covaried positively with neuronal activity in a predominantly linear manner, with a small quadratic contribution. Simultaneously, other cortical areas corresponding to the nonstimulated limbs were found to covary negatively and linearly in the hemispheres ipsilateral and contralateral to the stimulus. These concurrent and bilateral cortical dynamics, as well as the intraregional features of this neurovascular coupling, are both more complex than had been considered to date, with considerable implications.
引用
收藏
页码:661 / 668
页数:8
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