Haemostasis in patients with Behcet's disease

被引：32

作者：

Demirer, S ^{[1
]}

Sengül, N ^{[1
]}

Yerdel, MA ^{[1
]}

Tüzüner, A ^{[1
]}

Ulus, AT ^{[1
]}

Gürler, A ^{[1
]}

Bergqvist, D ^{[1
]}

Siegbahn, A ^{[1
]}

Karacagil, S ^{[1
]}

机构：

[1] Ankara Univ Hosp, Dept Surg, Ankara, Turkey

来源：

EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY | 2000年 / 19卷 / 06期

关键词：

D O I：

10.1053/ejvs.2000.1091

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Aim: to determine whether Behcet's disease affects haemostatic function. Setting: University Hospital, Turkey. Patients: one hundred and twenty-seven consecutive patients with Behcet's disease, 34 of whom with a history of vascular involvement. Methods: pr prothrombin fragment 1 + 2 tissue plasminogen activator, protein S and C, antithrombin, fibrinogen, von Willebrand factor, thrombomodulin and prothrombin time (PT) were measured in patient plasma. Results: soluble thrombomodulin was significantly lower and von Willebrand factor (vWF) and tissue plasminogen activator (IPA) significantly higher in Bechet's patients. Patients with vascular involvement showed the highest levels of vWF and tPA. There was no activation of coagulation, not even in patients with an active disease at the time of sampling. Conclusion: there were indirect signs of endothelial activity or damage, particularly in patients with vascular involvement. Coagulation was not activated.

引用

页码：570 / 574

页数：5

共 28 条

[1] DEFECTIVE FIBRINOLYSIS IN BEHCET SYNDROME - SIGNIFICANCE AND POSSIBLE MECHANISMS [J].