Effect of a hypolipidemic drug, di (2-ethylhexyl) phthalate, on mRNA-expression associated fatty acid and acetate metabolism in rat tissues

被引：27

作者：

Itsuki-Yoneda, Ai ^{[1
]}

Kimoto, Masumi ^{[1
]}

Tsuji, Hideaki ^{[1
]}

Hiemori, Miki ^{[1
]}

Yamashita, Hiromi ^{[1
]}

机构：

[1] Okayama Prefectural Univ, Fac Hlth & Welf Sci, Dept Nutr Sci, Okayama 7191197, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2007年 / 71卷 / 02期

关键词：

peroxisome proliferator; fatty acid metabolism; beta-oxidation; acetate metabolism; di (2-ethylhexyl) phthalate;

D O I：

10.1271/bbb.60478

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Di (2-ehtylhexyl) phthalate (DEHP) is a peroxisome proliferator and a drug having a hypolipidemic effect. The body-weight change of rats treated with DEHP was lower than that of rats in an untreated control group. Expressions of long-chain acyl-CoA dehydrogenase and 3-ketoacyl-CoA thiolase, which are involved in fatty acid oxidation and acetate formation in mitochondria, showed an increase in the liver and testes of rats treated with DEHP. The expression of acetyl-CoA synthetase I was significantly decreased in the testes and relatively decreased in the liver, while the expression of acetylCoA synthetase 2 was significantly increased in the heart. Furthermore, the expressions of acetyl-CoA carboxylase in heart and testes showed a tendency to decrease. From these results, it is suggested that DEHP-treatment increased fatty acid oxidation and acetate formation in liver and testes, and that acetate utilization was increased in peripheral tissues such as the heart.

引用

页码：414 / 420

页数：7

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