Biophysical and radiobiological aspects of heavy charged particles

被引：12

作者：

Desouky, Omar ^{[1
]}

Zhou, Guangming ^{[2
]}

机构：

[1] Egyptian Atom Energy Author, Dept Radiat Phys, Natl Ctr Radiat Res & Technol, Cairo, Egypt

[2] Chinese Acad Sci, Inst Modern Phys, Dept Space Radiobiol, Lanzhou, Peoples R China

来源：

JOURNAL OF TAIBAH UNIVERSITY FOR SCIENCE | 2016年 / 10卷 / 02期

关键词：

Heavy charged particles; Biophysics; Radiobiology radiotherapy and space mission; DOUBLE-STRAND BREAKS; TUMOR-THERAPY; DNA-DAMAGE; RADIATION; REPAIR; IMPLEMENTATION; PREVENTION; PHYSICS; IONS;

D O I：

10.1016/j.jtusci.2015.02.014

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Heavy-ion beams have unique biophysical and radiobiological properties, such as the inverted depth dose profile compared to photon beams, relative biological effectiveness and oxygen enhancement ratio. These physical and biological properties are much more favourable than those of photon radiotherapy and can be used to treat tumours efficiently. During a long-term stay in space, astronauts will be constantly exposed to low-dose space radiation. Thus, space radiation is one of the major health-related concerns for space exploration. This review summarizes the biophysical and biological properties of charged particles and their advantage in radiotherapy. In addition, we briefly reviewed the importance of the heavy ion during space flight and how to suppress its deleterious effects. (C) 2015 The Authors. Production and hosting by Elsevier B.V. on behalf of Taibah University.

引用

页码：187 / 194

页数：8

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