The antipsychotic potential of subtype-selective 5-HT receptor ligands based on interactions with mesolimbic dopamine systems

被引：0
|
作者：
Tricklebank, MD [1 ]
机构：
[1] MERCK SHARP & DOHME RES LABS, NEUROSCI RES CTR, HARLOW CM20 2QR, ESSEX, ENGLAND
来源：
BEHAVIOURAL BRAIN RESEARCH | 1996年 / 73卷 / 1-2期
关键词：
5-HT; dopamine; receptor subtype; mesolimbic; clozapine; schizophrenia;
D O I：
暂无
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
Many neurochemical, electrophysiological and behavioural studies have shown how 5-HT and dopamine neuronal systems are able to interact and it is highly likely that the therapeutic benefits of clozapine-like atypical antipsychotic drugs are achieved by the modulation of such interactions. There are, however, at least fourteen subtypes of 5-HT receptor and five subtypes of dopamine receptor expressed in rodent and/or human brain and the optimum combination of receptor affinities required for maximum therapeutic benefit remains enigmatic.
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页码：15 / 17
页数：3
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