P53 and prognosis: New insights and further complexity

被引：245
作者：
Vousden, KH
Prives, C
机构：
[1] Beatson Inst Canc Res, Glasgow G61 1BD, Lanark, Scotland
[2] Columbia Univ, Dept Biol Sci, New York, NY 10027 USA
来源：
CELL | 2005年 / 120卷 / 01期
关键词：
D O I：
10.1016/j.cell.2004.12.027
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Despite the massive amount of knowledge that has accumulated about p53, there is still much to learn about its role in tumor suppression. New papers now provide evidence that levels of Mdm2 in humans or presence of mutant forms of p53 in mice can have profound impacts on survival and tumorigenesis. These findings may lead to new diagnostic and therapeutic approaches to treating cancer patients.
引用
收藏
页码：7 / 10
页数：4
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