Synthesis of 5′-C-branched thymidines and conversion to phosphoramidites

被引：9

作者：

Wang, GY ^{[1
]}

Middleton, PJ ^{[1
]}

机构：

[1] ICN Pharmaceut Inc, Dept Res, Costa Mesa, CA 92626 USA

来源：

NUCLEOSIDES & NUCLEOTIDES | 1998年 / 17卷 / 06期

关键词：

D O I：

10.1080/07328319808004219

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Thymidine was converted to its 5'-epoxy derivative, which was reacted with nucleophiles to give 5'-C-aminomethyl-, 5'-C-bromomethyl-, 5'-C-cyanomethyl, and 5'-C-methoxymethylthymidine derivatives with defined stereochemistry. 5'-C-ally-, 5'-C-hydroxymethyl-, 5'-C-hydroxypropyl-, and 5'-C-(imidazole-4-acetamido)metbylthymidine derivatives were also prepared. The 5'-C-branched thymidines were converted to the corresponding phosphoramidites.

引用

页码：1033 / 1051

页数：19

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