Synthesis of 5′-C-branched thymidines and conversion to phosphoramidites

被引：9
|
作者：
Wang, GY [1 ]
Middleton, PJ [1 ]
机构：
[1] ICN Pharmaceut Inc, Dept Res, Costa Mesa, CA 92626 USA
来源：
NUCLEOSIDES & NUCLEOTIDES | 1998年 / 17卷 / 06期
关键词：
D O I：
10.1080/07328319808004219
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Thymidine was converted to its 5'-epoxy derivative, which was reacted with nucleophiles to give 5'-C-aminomethyl-, 5'-C-bromomethyl-, 5'-C-cyanomethyl, and 5'-C-methoxymethylthymidine derivatives with defined stereochemistry. 5'-C-ally-, 5'-C-hydroxymethyl-, 5'-C-hydroxypropyl-, and 5'-C-(imidazole-4-acetamido)metbylthymidine derivatives were also prepared. The 5'-C-branched thymidines were converted to the corresponding phosphoramidites.
引用
收藏
页码：1033 / 1051
页数：19
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