An expedient synthesis and antimicrobial evaluation of ethoxyphthalimido derivatives of pyrimido[4,5-e]pyrimidine analogues from 1-(1H-benzimidazol-2-yl)guanidine

被引：0
作者：
Prajapat, Prakash [1 ]
Kumawat, Monika [1 ]
Kherodiya, Bhawana [1 ]
Talesara, Ganpat Lal [1 ]
机构：
[1] ML Sukhadia Univ, Dept Chem, Synthet Organ Chem Lab, Udaipur 313001, Rajasthan, India
来源：
JOURNAL OF THE INDIAN CHEMICAL SOCIETY | 2016年 / 93卷 / 05期
关键词：
Antimicrobial activity; guanidinobenzimidazole; pyrimidopyrimidine; ethoxyphthalimide; INHIBITORS; AGENTS; DESIGN;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
In the present study, convenient methods for the synthesis of new ethoxyphthalimidobenzimidazoles are elaborated. A novel-pyrimido[4,5-e]pyrimidin-dione (5) and a series of pyrimido[4,5-e]pyrimidin-diones (8a-e) have been designed and synthesized starting from 1-(1H-benzimidazol-2-yl)guanidine (2). The structures of all newly constructed derivatives were corroborated by analytical and spectral data (FT-IR, H-1 NMR and Mass) and chemical tests. Subsequently, compounds were subjected to their in vitro antimicrobial activity against a panel of pathogenic strains of bacteria and fungi. Some of the compounds were found to be equipotent or more potent than the reference drugs.
引用
收藏
页码：539 / 544
页数：6
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