Prognostic Biomarker ZNF311 and Its Correlation With Tumor Progression and Immune Infiltrates in Glioma

被引：4

作者：

Ge, Xinqi ^{[1
,2
]}

Jiang, Shichen ^{[3
]}

Wang, Ziheng ^{[2
,3
]}

Hu, Nan ^{[1
,2
]}

Jiang, Rui ^{[3
]}

Cai, Zishu ^{[3
]}

Wu, Bin ^{[3
]}

Zhang, Yu ^{[3
]}

Gong, Peipei ^{[3
]}

机构：

[1] Nantong Univ, Med Sch, Nantong, Peoples R China

[2] Nantong Univ, Dept Clin Biobank, Affiliated Hosp, Nantong, Peoples R China

[3] Nantong Univ, Dept Neurosurg, Affiliated Hosp, Nantong, Peoples R China

来源：

WORLD NEUROSURGERY | 2021年 / 151卷

关键词：

CGGA; CIBERSORT; GEPIA; GLIOMA; ZNF311; PROLIFERATION; MACROPHAGES; MIGRATION; MUTATIONS;

D O I：

10.1016/j.wneu.2021.03.064

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

-BACKGROUND: Gliomas, particularly high-grade gli-omas, are the most common primary brain tumors. From the Chinese Glioma Genome Atlas (CGGA) database, the re-lationships between the altered molecular pathways and gliomas could be easily observed. A close connection in the occurrence of the pathogenesis exists between the microenvironment, the glioma, and the associated genes. - METHODS: Validation of the role of ZNF311 oncogene was confirmed by data from the CGGA dataset on glio-blastoma and low-grade glioma. Furthermore, we used CIBERSORT to analyze the correlation between ZNF311 and cancer immune infiltrates. - RESULTS: According to our analysis, ZNF311 was expressed higher in patients with grade-depended glioma with poor prognosis. In addition, we obtained valuable prognostic results between isocitrate dehydrogenase 1 (IDH1) and ZNF311 through the analysis of integrated cor -relations. Similarly, we simultaneously revealed the prog-nostic results between 1p/19q and ZNF311. In addition, we found that ZNF311 is correlated with a large number of tumor-infiltrating immune cells. - CONCLUSIONS: Based on the study findings, we conclude that ZNF311 is potentially a novel biomarker for assessing prognosis and immune infiltration in glioblas-toma and diffuse glioma cases. - RESULTS: According to our analysis, ZNF311 was expressed higher in patients with grade-depended glioma with poor prognosis. In addition, we obtained valuable prognostic results between isocitrate dehydrogenase 1 (IDH1) and ZNF311 through the analysis of integrated correlations. Similarly, we simultaneously revealed the prognostic results between 1p/19q and ZNF311. In addition, we found that ZNF311 is correlated with a large number of tumor-infiltrating immune cells. - CONCLUSIONS: Based on the study findings, we conclude that ZNF311 is potentially a novel biomarker for assessing prognosis and immune infiltration in glioblas

引用

页码：E37 / E46

页数：10

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