tRNA-derived fragments as New Hallmarks of Aging and Age-related Diseases

被引：19

作者：

Yuan, Ya ^{[1
]}

Li, Jiamei ^{[1
]}

He, Zhi ^{[1
]}

Fan, Xiaolan ^{[1
,2
]}

Mao, Xueping ^{[1
,2
]}

Yang, Mingyao ^{[1
,2
]}

Yang, Deying ^{[1
,2
]}

机构：

[1] Sichuan Agr Univ, Inst Anim Genet & Breeding, Chengdu 611130, Sichuan, Peoples R China

[2] Sichuan Agr Univ, Farm Anim Genet Resources Explorat & Innovat Key, Chengdu 611130, Sichuan, Peoples R China

来源：

AGING AND DISEASE | 2021年 / 12卷 / 05期

基金：

中国国家自然科学基金;

关键词：

tRFs; regulation mechanisms; aging; age-related diseases; PROMOTES CELL-PROLIFERATION; SMALL NONCODING RNAS; CYTOCHROME-C; LUNG-CANCER; TRANSLATION; MODEL; ROLES; RISK; BIOGENESIS; EXPRESSION;

D O I：

10.14336/AD.2021.0115

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

tRNA-derived fragments (tRFs), which are non-coding RNAs produced via tRNA cleavage with lengths of 14 to 50 nucleotides, originate from precursor tRNAs or mature tRNAs and exist in a wide range of organisms. tRFs are produced not by random fracture of tRNAs but by specific mechanisms. Considerable evidence shows that tRFs are detectable in model organisms of different ages and are associated with age-related diseases in humans, such as cancer and neurodegenerative diseases. In this literature review, the origin and classification of tRFs and the regulatory mechanisms of tRFs in aging and age-related diseases are summarized. We also describe the available tRF databases and research techniques and lay a foundation for the exploration of tRFs as biomarkers for the diagnosis and treatment of aging and age-related diseases.

引用

页码：1304 / 1322

页数：19

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