Amylolytic activity of IgM and IgG antibodies from patients with multiple sclerosis

被引：59
作者：
Saveliev, AN
Ivanen, DR
Kulminskaya, AA
Ershova, NA
Kanyshkova, TG
Buneva, VN
Mogelnitskii, AS
Doronin, BM
Favorova, OO
Nevinsky, GA
Neustroev, KN [1 ]
机构：
[1] Russian Acad Sci, Petersburg Nucl Phys Inst, St Petersburg 188300, Russia
[2] St Petersburg State Univ, Dept Biophys, St Petersburg, Russia
[3] Russian Acad Sci, Novosibirsk Bioorgan Chem Inst, Siberian Div, Novosibirsk, Russia
[4] Novosibirsk Army Hosp, Novosibirsk, Russia
[5] Novosibirsk State Med Univ, Novosibirsk, Russia
[6] Russian State Med Univ, Moscow 117437, Russia
来源：
IMMUNOLOGY LETTERS | 2003年 / 86卷 / 03期
基金：
俄罗斯基础研究基金会;
关键词：
human blood; multiple sclerosis; amylolytic activity; catalytic IgM and IgG;
D O I：
10.1016/S0165-2478(03)00042-7
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
IgG and IgM antibodies from the sera of patients with multiple sclerosis (MS) were found to possess amylolytic activity hydrolyzing alpha-(1 --> 4)-glucosyl linkages of maltooligosaccharides, glycogen, and several artificial substrates. Individual IgM fractions isolated from 54 analyzed patients with the clinically definite diagnoses of MS had approximately three orders of magnitude higher specific amylolytic activity than that for healthy donors, whereas IgG from only a few patients had high amylolytic activity. Strict criteria were used to-prove that the amylolytic activity of IgMs and IgGs is their intrinsic property and is not due to any enzyme contamination. Fab fragments produced from IgM and IgG fractions of the MS patients displayed the same amylolytic activity. IgMs from various patients demonstrated different modes of action in hydrolyzing maltooligosaccharides. (C) 2003 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：291 / 297
页数：7
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