ZCWPW1 is associated with late-onset Alzheimer's disease in Han Chinese: a replication study and meta-analyses

被引：20

作者：

Gao, Yu ^{[1
]}

Tan, Meng-Shan ^{[1
]}

Wang, Hui-Fu ^{[1
]}

Zhang, Wei ^{[2
]}

Wang, Zi-Xuan ^{[1
]}

Jiang, Teng ^{[3
]}

Yu, Jin-Tai ^{[1
]}

Tan, Lan ^{[1
]}

机构：

[1] Qingdao Univ, Sch Med, Qingdao Municipal Hosp, Dept Neurol, Qingdao 266071, Peoples R China

[2] Qingdao Univ, Sch Med, Qingdao Municipal Hosp, Dept Emergency, Qingdao 266071, Peoples R China

[3] Nanjing Med Univ, Nanjing Hosp 1, Dept Neurol, Nanjing, Jiangsu, Peoples R China

来源：

ONCOTARGET | 2016年 / 7卷 / 15期

基金：

中国国家自然科学基金;

关键词：

ZCWPW1; rs1476679; polymorphism; Alzheimer's disease; GENOME-WIDE ASSOCIATION; COMMON VARIANTS; IDENTIFIES VARIANTS; LOCI; SUSCEPTIBILITY; CLU; POLYMORPHISMS; CD2AP; EPHA1; CD33;

D O I：

10.18632/oncotarget.7945

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Recently, a large genome-wide association study (GWAS) has identified a novel variant (rs1476679) within ZCWPW1 showing strong association with late-onset Alzheimer's disease (LOAD) in Caucasian. However, the effect of rs1476679 on other populations remains unclear. In order to explore whether rs1476679 is also associated with the LOAD risk in other ethnic groups, we recruited 2350 unrelated Northern Han Chinese subjects, which include 992 LOAD patients and 1358 healthy controls. Analysis of data from these subjects suggests that the rs1476679 polymorphism is significantly associated with the LOAD (genotype P = 0.017, allele P = 0.044). The logistic regression reveals the C allele at rs1476679 is a protective factor for LOAD in the dominant model (OR = 0.779, 95%CI = 0.659-0.921, Pc = 0.009) adjusting for gender, age and APOE epsilon 4 status. Furthermore, rs1476679 can decrease the AD risk (Dominant: OR = 0.733, 95% CI = 0.607-0.884, Pc = 0.006; Additive: OR = 0.820, 95% CI = 0.708-0.950, Pc = 0.048) in APOE epsilon 4 non-carriers after stratification. Furthermore, meta-analysis of 82525 individuals confirmed that rs1476679 within ZCWPW1 decreased the risk of LOAD (OR = 0.91, 95% CI = 0.89-0.94). To summarize, the rs1476679 polymorphism in ZCWPW1 is associated with LOAD in Northern Han Chinese population.

引用

页码：20305 / 20311

页数：7

共 25 条

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Pahwa, Jaspreet Singh ;

Moskvina, Valentina ;

Dowzell, Kimberley ;

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Kuwasako, Kanako ;

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Matsuda, Takayoshi ;

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Harold, Denise ;

Sims, Rebecca ;

Gerrish, Amy ;

Lambert, Jean-Charles ;

Carrasquillo, Minerva M. ;

Abraham, Richard ;

Hamshere, Marian L. ;

Pahwa, Jaspreet Singh ;

Moskvina, Valentina ;

Dowzell, Kimberley ;

Jones, Nicola ;

Stretton, Alexandra ;

Thomas, Charlene ;

Richards, Alex ;

Ivanov, Dobril ;

Widdowson, Caroline ;

Chapman, Jade ;

Lovestone, Simon ;

Powell, John ;

Proitsi, Petroula ;

Lupton, Michelle K. ;

Brayne, Carol ;

Rubinsztein, David C. ;

Gill, Michael ;

Lawlor, Brian ;

Lynch, Aoibhinn ;

Brown, Kristelle S. ;

Passmore, Peter A. ;

Craig, David ;

McGuinness, Bernadette ;

Todd, Stephen ;

Holmes, Clive ;

Mann, David ;

Smith, A. David ;

Beaumont, Helen ;

Warden, Donald ;

Wilcock, Gordon ;

Love, Seth ;

Kehoe, Patrick G. ;

Hooper, Nigel M. ;

Vardy, Emma R. L. C. ;

Hardy, John ;

Mead, Simon ;

Fox, Nick C. ;

Rossor, Martin ;

Collinge, John ;

Maier, Wolfgang ;

Jessen, Frank ;

Ruether, Eckart .

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Jiao, Bin ;

Liu, Xiaoyan ;

Zhou, Lin ;

Wang, Maggie Haitian ;

Zhou, Yafang ;

Xiao, Tingting ;

Zhang, Weiwei ;

Sun, Rui ;

Waye, Mary Miu Yee ;

Tang, Beisha ;

Shen, Lu .

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Lambert, Jean-Charles ;

Ibrahim-Verbaas, Carla A. ;

Harold, Denise ;

Naj, Adam C. ;

Sims, Rebecca ;

Bellenguez, Celine ;

Jun, Gyungah ;

DeStefano, Anita L. ;

Bis, Joshua C. ;

Beecham, Gary W. ;

Grenier-Boley, Benjamin ;

Russo, Giancarlo ;

Thornton-Wells, Tricia A. ;

Jones, Nicola ;

Smith, Albert V. ;

Chouraki, Vincent ;

Thomas, Charlene ;

Ikram, M. Arfan ;

Zelenika, Diana ;

Vardarajan, Badri N. ;

Kamatani, Yoichiro ;

Lin, Chiao-Feng ;

Gerrish, Amy ;

Schmidt, Helena ;

Kunkle, Brian ;

Dunstan, Melanie L. ;

Ruiz, Agustin ;

Bihoreau, Marie-Therese ;

Choi, Seung-Hoan ;

Reitz, Christiane ;

Pasquier, Florence ;

Hollingworth, Paul ;

Ramirez, Alfredo ;

Hanon, Olivier ;

Fitzpatrick, Annette L. ;

Buxbaum, Joseph D. ;

Campion, Dominique ;

Crane, Paul K. ;

Baldwin, Clinton ;

Becker, Tim ;

Gudnason, Vilmundur ;

Cruchaga, Carlos ;

Craig, David ;

Amin, Najaf ;

Berr, Claudine ;

Lopez, Oscar L. ;

De Jager, Philip L. ;

Deramecourt, Vincent ;

Johnston, Janet A. ;

Evans, Denis .

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Lambert, Jean-Charles ;

Heath, Simon ;

Even, Gael ;

Campion, Dominique ;

Sleegers, Kristel ;

Hiltunen, Mikko ;

Combarros, Onofre ;

Zelenika, Diana ;

Bullido, Maria J. ;

Tavernier, Beatrice ;

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← 1 2 3 →

共 25 条

[1] Genome-Wide Association Meta-analysis of Neuropathologic Features of Alzheimer's Disease and Related Dementias [J].

Beecham, Gary W. ;

Hamilton, Kara ;

Naj, Adam C. ;

Martin, Eden R. ;

Huentelman, Matt ;

Myers, Amanda J. ;

Corneveaux, Jason J. ;

Hardys, John ;

Vonsatte, Jean-Paul, I ;

Younkin, Steven G. ;

Bennett, David A. ;

De Jager, Philip L. ;

Larson, Eric B. ;

Crane, Paul K. ;

Kamboh, M. Ilyas ;

Kofler, Julia K. ;

Mash, Deborah C. ;

Duque, Linda ;

Gilbertl, John R. ;

Gwirtsman, Harry ;

Buxbaum, Joseph D. ;

Kramer, Patricia ;

Dickson, Dennis W. ;

Farrer, Lindsay A. ;

Frosch, Matthew P. ;

Ghetti, Bernardino ;

Haines, Jonathan L. ;

Hyman, Bradley T. ;

Kuku, Walter A. ;

Mayeux, Richard P. ;

Pericak-Vancel, Margaret A. ;

Schneider, Julie A. ;

Trojanowski, John Q. ;

Reiman, Eric M. ;

Schellenberg, Gerard D. ;

Montine, Thomas J. .

PLOS GENETICS, 2014, 10 (09)

[2] Replication of CLU, CR1, and PICALM Associations With Alzheimer Disease [J].

Carrasquillo, Minerva M. ;

Belbin, Olivia ;

Hunter, Talisha A. ;

Ma, Li ;

Bisceglio, Gina D. ;

Zou, Fanggeng ;

Crook, Julia E. ;

Pankratz, V. Shane ;

Dickson, Dennis W. ;

Graff-Radford, Neill R. ;

Petersen, Ronald C. ;

Morgan, Kevin ;

Younkin, Steven G. .

ARCHIVES OF NEUROLOGY, 2010, 67 (08) :961-964

[3] Gene-Wide Analysis Detects Two New Susceptibility Genes for Alzheimer's Disease [J].

Escott-Price, Valentina ;

Bellenguez, Celine ;

Wang, Li-San ;

Choi, Seung-Hoan ;

Harold, Denise ;

Jones, Lesley ;

Holmans, Peter ;

Gerrish, Amy ;

Vedernikov, Alexey ;

Richards, Alexander ;

DeStefano, Anita L. ;

Lambert, Jean-Charles ;

Ibrahim-Verbaas, Carla A. ;

Naj, Adam C. ;

Sims, Rebecca ;

Jun, Gyungah ;

Bis, Joshua C. ;

Beecham, Gary W. ;

Grenier-Boley, Benjamin ;

Russo, Giancarlo ;

Thornton-Wells, Tricia A. ;

Denning, Nicola ;

Smith, Albert V. ;

Chouraki, Vincent ;

Thomas, Charlene ;

Ikram, M. Arfan ;

Zelenika, Diana ;

Vardarajan, Badri N. ;

Kamatani, Yoichiro ;

Lin, Chiao-Feng ;

Schmidt, Helena ;

Kunkle, Brian ;

Dunstan, Melanie L. ;

Vronskaya, Maria ;

Johnson, Andrew D. ;

Ruiz, Agustin ;

Bihoreau, Marie-Therese ;

Reitz, Christiane ;

Pasquier, Florence ;

Hollingworth, Paul ;

Hanon, Olivier ;

Fitzpatrick, Annette L. ;

Buxbaum, Joseph D. ;

Campion, Dominique ;

Crane, Paul K. ;

Baldwin, Clinton ;

Becker, Tim ;

Gudnason, Vilmundur ;

Cruchaga, Carlos ;

Craig, David .

PLOS ONE, 2014, 9 (06)

[4] TREM2 Variants in Alzheimer's Disease [J].

Guerreiro, Rita ;

Wojtas, Aleksandra ;

Bras, Jose ;

Carrasquillo, Minerva ;

Rogaeva, Ekaterina ;

Majounie, Elisa ;

Cruchaga, Carlos ;

Sassi, Celeste ;

Kauwe, John S. K. ;

Lupton, Michelle K. ;

Ryten, Mina ;

Brown, Kristelle ;

Lowe, James ;

Ridge, Perry G. ;

Hammer, Monia B. ;

Wakutani, Yosuke ;

Proitsi, Petroula ;

Newhouse, Stephen ;

Lohmann, Ebba ;

Erginel-Unaltuna, Nihan ;

Medway, Christopher ;

Hanagasi, Hasmet ;

Troakes, Claire ;

Gurvit, Hakan ;

Bilgic, Basar ;

Al-Sarraj, Safa ;

Benitez, Bruno ;

Cooper, Breanna ;

Carrell, David ;

Emre, Murat ;

Zou, Fanggeng ;

Ma, Li ;

Murray, Melissa E. ;

Dickson, Dennis W. ;

Younkin, Steven ;

Hazrati, Lilinaz ;

Petersen, Ronald C. ;

Corcoran, Christopher D. ;

Cai, Yefei ;

Oliveira, Catarina ;

Ribeiro, Maria Helena ;

Santana, Isabel ;

Tschanz, JoAnn T. ;

Gibbs, J. Raphael ;

Norton, Maria C. ;

Kloszewska, Iwona ;

Mecocci, Patrizia ;

Soininen, Hilkka ;

Tsolaki, Magda ;

Vellas, Bruno .

NEW ENGLAND JOURNAL OF MEDICINE, 2013, 368 (02) :117-127

[5] Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease [J].

Harold, Denise ;

Abraham, Richard ;

Hollingworth, Paul ;

Sims, Rebecca ;

Gerrish, Amy ;

Hamshere, Marian L. ;

Pahwa, Jaspreet Singh ;

Moskvina, Valentina ;

Dowzell, Kimberley ;

Williams, Amy ;

Jones, Nicola ;

Thomas, Charlene ;

Stretton, Alexandra ;

Morgan, Angharad R. ;

Lovestone, Simon ;

Powell, John ;

Proitsi, Petroula ;

Lupton, Michelle K. ;

Brayne, Carol ;

Rubinsztein, David C. ;

Gill, Michael ;

Lawlor, Brian ;

Lynch, Aoibhinn ;

Morgan, Kevin ;

Brown, Kristelle S. ;

Passmore, Peter A. ;

Craig, David ;

McGuinness, Bernadette ;

Todd, Stephen ;

Holmes, Clive ;

Mann, David ;

Smith, A. David ;

Love, Seth ;

Kehoe, Patrick G. ;

Hardy, John ;

Mead, Simon ;

Fox, Nick ;

Rossor, Martin ;

Collinge, John ;

Maier, Wolfgang ;

Jessen, Frank ;

Schuermann, Britta ;

van den Bussche, Hendrik ;

Heuser, Isabella ;

Kornhuber, Johannes ;

Wiltfang, Jens ;

Dichgans, Martin ;

Froelich, Lutz ;

Hampel, Harald ;

Huell, Michael .

NATURE GENETICS, 2009, 41 (10) :1088-U61

[6] Structural Insight into the Zinc Finger CW Domain as a Histone Modification Reader [J].

He, Fahu ;

Umehara, Takashi ;

Saito, Kohei ;

Harada, Takushi ;

Watanabe, Satoru ;

Yabuki, Takashi ;

Kigawa, Takanori ;

Takahashi, Mari ;

Kuwasako, Kanako ;

Tsuda, Kengo ;

Matsuda, Takayoshi ;

Aoki, Masaaki ;

Seki, Eiko ;

Kobayashi, Naohiro ;

Guentert, Peter ;

Yokoyama, Shigeyuki ;

Muto, Yutaka .

STRUCTURE, 2010, 18 (09) :1127-1139

[7] Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease [J].

Hollingworth, Paul ;

Harold, Denise ;

Sims, Rebecca ;

Gerrish, Amy ;

Lambert, Jean-Charles ;

Carrasquillo, Minerva M. ;

Abraham, Richard ;

Hamshere, Marian L. ;

Pahwa, Jaspreet Singh ;

Moskvina, Valentina ;

Dowzell, Kimberley ;

Jones, Nicola ;

Stretton, Alexandra ;

Thomas, Charlene ;

Richards, Alex ;

Ivanov, Dobril ;

Widdowson, Caroline ;

Chapman, Jade ;

Lovestone, Simon ;

Powell, John ;

Proitsi, Petroula ;

Lupton, Michelle K. ;

Brayne, Carol ;

Rubinsztein, David C. ;

Gill, Michael ;

Lawlor, Brian ;

Lynch, Aoibhinn ;

Brown, Kristelle S. ;

Passmore, Peter A. ;

Craig, David ;

McGuinness, Bernadette ;

Todd, Stephen ;

Holmes, Clive ;

Mann, David ;

Smith, A. David ;

Beaumont, Helen ;

Warden, Donald ;

Wilcock, Gordon ;

Love, Seth ;

Kehoe, Patrick G. ;

Hooper, Nigel M. ;

Vardy, Emma R. L. C. ;

Hardy, John ;

Mead, Simon ;

Fox, Nick C. ;

Rossor, Martin ;

Collinge, John ;

Maier, Wolfgang ;

Jessen, Frank ;

Ruether, Eckart .

NATURE GENETICS, 2011, 43 (05) :429-+

[8] Polygenic Analysis of Late-Onset Alzheimer's Disease from Mainland China [J].

Jiao, Bin ;

Liu, Xiaoyan ;

Zhou, Lin ;

Wang, Maggie Haitian ;

Zhou, Yafang ;

Xiao, Tingting ;

Zhang, Weiwei ;

Sun, Rui ;

Waye, Mary Miu Yee ;

Tang, Beisha ;

Shen, Lu .

PLOS ONE, 2015, 10 (12)

[9] Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease [J].

Lambert, Jean-Charles ;

Ibrahim-Verbaas, Carla A. ;

Harold, Denise ;

Naj, Adam C. ;

Sims, Rebecca ;

Bellenguez, Celine ;

Jun, Gyungah ;

DeStefano, Anita L. ;

Bis, Joshua C. ;

Beecham, Gary W. ;

Grenier-Boley, Benjamin ;

Russo, Giancarlo ;

Thornton-Wells, Tricia A. ;

Jones, Nicola ;

Smith, Albert V. ;

Chouraki, Vincent ;

Thomas, Charlene ;

Ikram, M. Arfan ;

Zelenika, Diana ;

Vardarajan, Badri N. ;

Kamatani, Yoichiro ;

Lin, Chiao-Feng ;

Gerrish, Amy ;

Schmidt, Helena ;

Kunkle, Brian ;

Dunstan, Melanie L. ;

Ruiz, Agustin ;

Bihoreau, Marie-Therese ;

Choi, Seung-Hoan ;

Reitz, Christiane ;

Pasquier, Florence ;

Hollingworth, Paul ;

Ramirez, Alfredo ;

Hanon, Olivier ;

Fitzpatrick, Annette L. ;

Buxbaum, Joseph D. ;

Campion, Dominique ;

Crane, Paul K. ;

Baldwin, Clinton ;

Becker, Tim ;

Gudnason, Vilmundur ;

Cruchaga, Carlos ;

Craig, David ;

Amin, Najaf ;

Berr, Claudine ;

Lopez, Oscar L. ;

De Jager, Philip L. ;

Deramecourt, Vincent ;

Johnston, Janet A. ;

Evans, Denis .

NATURE GENETICS, 2013, 45 (12) :1452-U206

[10] Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease [J].

Lambert, Jean-Charles ;

Heath, Simon ;

Even, Gael ;

Campion, Dominique ;

Sleegers, Kristel ;

Hiltunen, Mikko ;

Combarros, Onofre ;

Zelenika, Diana ;

Bullido, Maria J. ;

Tavernier, Beatrice ;

Letenneur, Luc ;

Bettens, Karolien ;

Berr, Claudine ;

Pasquier, Florence ;

Fievet, Nathalie ;

Barberger-Gateau, Pascale ;

Engelborghs, Sebastiaan ;

De Deyn, Peter ;

Mateo, Ignacio ;

Franck, Ana ;

Helisalmi, Seppo ;

Porcellini, Elisa ;

Hanon, Olivier ;

de Pancorbo, Marian M. ;

Lendon, Corinne ;

Dufouil, Carole ;

Jaillard, Celine ;

Leveillard, Thierry ;

Alvarez, Victoria ;

Bosco, Paolo ;

Mancuso, Michelangelo ;

Panza, Francesco ;

Nacmias, Benedetta ;

Bossu, Paola ;

Piccardi, Paola ;

Annoni, Giorgio ;

Seripa, Davide ;

Galimberti, Daniela ;

Hannequin, Didier ;

Licastro, Federico ;

Soininen, Hilkka ;

Ritchie, Karen ;

Blanche, Helene ;

Dartigues, Jean-Francois ;

Tzourio, Christophe ;

Gut, Ivo ;

Van Broeckhoven, Christine ;

Alperovitch, Annick ;

Lathrop, Mark ;

Amouyel, Philippe .

NATURE GENETICS, 2009, 41 (10) :1094-U68

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