Synthesis and in vitro evaluation of novel tetralin-pyrazolo[3,4-b]pyridine hybrids as potential anticancer agents

被引：15

作者：

Hamza, Eman Kh ^{[1
]}

Hamdy, Nehal A. ^{[1
]}

Zarie, Eman S. ^{[2
,3
]}

Fakhr, Issa M. I. ^{[1
]}

Elwahy, Ahmed H. M. ^{[4
]}

Awad, Hanem M. ^{[5
]}

机构：

[1] Natl Res Ctr, Appl Organ Chem Dept, Giza, Egypt

[2] Aalto Univ, Sch Chem Engn, Dept Chem & Mat Sci & Engn, Nanochem & Nanoengn, Espoo, Finland

[3] Natl Res Ctr, Therapeut Chem Dept, Pharmaceut & Drug Ind Res Div, Giza, Egypt

[4] Cairo Univ, Fac Sci, Dept Chem, Giza, Egypt

[5] Natl Res Ctr, Dept Tanning Mat & Leather Technol, Cairo, Egypt

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2020年 / 57卷 / 01期

关键词：

BIOLOGICAL EVALUATION; PYRIDINE-DERIVATIVES; ANALGESIC ACTIVITY; DESIGN; PIM-1; INHIBITORS; CHEMISTRY; THIAZOLIDINONES; DISCOVERY; MOIETY;

D O I：

10.1002/jhet.3764

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

New hybrids of tetralin-pyrazolo[3,4-b]pyridine were synthesized in good yields. The structures of newly synthesized compounds were confirmed by IR, NMR, MS, and elemental analyses. Some of the new compounds were in vitro evaluated as antiproliferative candidates against two human cancer cell lines (HCT116 and MCF-7). Most of the examined derivatives showed promising anticancer activity.

引用

页码：182 / 196

页数：15

共 50 条

[21] Harnessing Cascade Suzuki-Cyclization Reactions of Pyrazolo[3,4-b]pyridine for the Synthesis of Tetracyclic Fused Heteroaromatics
Lavrard, Hubert
Popowycz, Florence
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2017, 2017 (03) : 600 - 608
[22] Microwave-assisted synthesis of pyrazolo[3,4-b]pyridine derivatives (microreview)
Dyadyuchenko, Ludmila V.
Dmitrieva, Irina G.
CHEMISTRY OF HETEROCYCLIC COMPOUNDS, 2020, 56 (11) : 1414 - 1416
[23] Synthesis and characterization of new 1H-pyrazolo[3,4-b]pyridine phosphoramidate derivatives
Pedrosa, Leandro F.
de Macedo, William P.
Furtado, Antonia C. R.
Guedes, Guilherme P.
Borges, Julio C.
Resende, Jackson A. L. C.
Vaz, Maria G. F.
Bernardino, Alice M. R.
de Souza, Marcos C.
ARKIVOC, 2014, : 38 - 50
[24] Pyridine-Ureas as Potential Anticancer Agents: Synthesis and In Vitro Biological Evaluation
El-Naggar, Mohamed
Almahli, Hadia
Ibrahim, Hany S.
Eldehna, Wagdy M.
Abdel-Aziz, Hatem A.
MOLECULES, 2018, 23 (06):
[25] Convenient synthesis and anticancer evaluation of novel pyrazolyl-thiophene, thieno[3,2-b]pyridine, pyrazolo[3,4-d]thieno[3,2-b]pyridine and pyrano[2,3-d]thieno[3,2-b]pyridine derivatives
Masaret, Ghada S.
JOURNAL OF HETEROCYCLIC CHEMISTRY, 2021, 58 (06) : 1344 - 1358
[26] Regioselective Synthesis, Spectroscopic Characterization, and Computational Chemical Study of Spiro[Indoline-3,4'-Pyrazolo[3,4-b] Pyridine Derivatives as Agrochemical Agents
Ibrahim, Nasser Abdelmoneim
El-Kaed, Sarah Ahmed
Rizk, Sameh Ahmed
Ali, Ali Khalil
POLYCYCLIC AROMATIC COMPOUNDS, 2022, 42 (08) : 5567 - 5584
[27] Synthesis and Reactions of Fused Pyrazolo[3,4-b]Pyridine Derivatives: Insecticidal Activity and Digestive Dysfunction against Mosquito Larvae
Abeed, Ahmed A. O.
El-Emary, Talaat I.
Youssef, Mohamed S. K.
Hefzy, Ibrahim
Ibrahim, Ahmed M. A.
CURRENT ORGANIC CHEMISTRY, 2023, 27 (10) : 852 - 859
[28] Pyrazolopyridines I: Synthesis of Some Pyrazolo[3,4-b]pyridine-4-carboxylates
Maqbool, Tahir
Khan, Misbahul Ain
Khan, Muhammad Naeem
Elliott, Mark C.
Munawar, Munawar Ali
Nasrullah, Muhammad
Bhatti, Abdul Waheed
Nazeer, Areesha
Lin, Whei-Oh
ASIAN JOURNAL OF CHEMISTRY, 2013, 25 (14) : 7715 - 7718
[29] 1H-Pyrazolo[3,4-b]pyridines: Synthesis and Biomedical Applications
Donaire-Arias, Ana
Montagut, Ana Maria
Puig de la Bellacasa, Raimon
Estrada-Tejedor, Roger
Teixido, Jordi
Borrell, Jose I.
MOLECULES, 2022, 27 (07):
[30] Synthesis of Novel Benzamide- piperazine-sulfonamide Hybrids as Potential Anticancer Agents
Rao, B. Ramalingeswara
Katiki, Mohana Rao
Kommula, Dileep
Narayanan, SaiShyam
Anto, Ruby John
Murty, M. S. R.
CROATICA CHEMICA ACTA, 2019, 92 (03) : 393 - 402

← 1 2 3 4 5 →