Synthesis and in vitro evaluation of novel tetralin-pyrazolo[3,4-b]pyridine hybrids as potential anticancer agents

被引：16

作者：

Hamza, Eman Kh ^{[1
]}

Hamdy, Nehal A. ^{[1
]}

Zarie, Eman S. ^{[2
,3
]}

Fakhr, Issa M. I. ^{[1
]}

Elwahy, Ahmed H. M. ^{[4
]}

Awad, Hanem M. ^{[5
]}

机构：

[1] Natl Res Ctr, Appl Organ Chem Dept, Giza, Egypt

[2] Aalto Univ, Sch Chem Engn, Dept Chem & Mat Sci & Engn, Nanochem & Nanoengn, Espoo, Finland

[3] Natl Res Ctr, Therapeut Chem Dept, Pharmaceut & Drug Ind Res Div, Giza, Egypt

[4] Cairo Univ, Fac Sci, Dept Chem, Giza, Egypt

[5] Natl Res Ctr, Dept Tanning Mat & Leather Technol, Cairo, Egypt

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2020年 / 57卷 / 01期

关键词：

BIOLOGICAL EVALUATION; PYRIDINE-DERIVATIVES; ANALGESIC ACTIVITY; DESIGN; PIM-1; INHIBITORS; CHEMISTRY; DISCOVERY; MOIETY;

D O I：

10.1002/jhet.3764

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

New hybrids of tetralin-pyrazolo[3,4-b]pyridine were synthesized in good yields. The structures of newly synthesized compounds were confirmed by IR, NMR, MS, and elemental analyses. Some of the new compounds were in vitro evaluated as antiproliferative candidates against two human cancer cell lines (HCT116 and MCF-7). Most of the examined derivatives showed promising anticancer activity.

引用

页码：182 / 196

页数：15

共 67 条

[1] Design of new metal complexes of 2-(3-amino-4,6-dimethyl-1H-pyrazolo[3,4-b]pyridin-1-yl)aceto-hydrazide: Synthesis, characterization, modelling and antioxidant activity [J].