The role of autophagy in pulmonary hypertension: a double-edge sword

被引：40

作者：

Chen, Rui ^{[1
]}

Jiang, Meiping ^{[1
]}

Li, Bo ^{[1
]}

Zhong, Wei ^{[1
]}

Wang, Zhongqun ^{[1
]}

Yuan, Wei ^{[1
]}

Yan, Jinchuan ^{[1
]}

机构：

[1] Jiangsu Univ, Affiliated Hosp, Dept Cardiol, Zhenjiang 212001, Jiangsu, Peoples R China

来源：

APOPTOSIS | 2018年 / 23卷 / 9-10期

基金：

中国国家自然科学基金;

关键词：

Pulmonary hypertension; Autophagy; Pulmonary vascular remodeling; Right ventricular myocyte; HYPOXIA-INDUCED AUTOPHAGY; NITRIC-OXIDE SYNTHASE; ARTERIAL-HYPERTENSION; ENDOTHELIAL-CELLS; MOLECULAR-MECHANISMS; MAMMALIAN TARGET; OXIDATIVE STRESS; HUMAN-DISEASE; II RECEPTOR; BECLIN;

D O I：

10.1007/s10495-018-1477-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Autophagy is a recycling process that degrades damaged or unneeded cellular components for renewal. Accumulating evidence suggests that dysregulation of autophagy is involved in pulmonary hypertension (PH). PH is a progressive disease characterized by persistent proliferation of apoptosis-resistant pulmonary vascular cells. However, reports on the role of autophagy in the development of PH are often conflicting. In this review, we discuss recent development in the field with emphasis on pulmonary arterial endothelial cells, pulmonary smooth muscle cells, right ventricular myocyte, as well as pharmacological strategies targeting the autophagic signaling pathway.

引用

页码：459 / 469

页数：11

共 74 条

[1] Emerging Mechanisms in Initiating and Terminating Autophagy [J].

Antonioli, Manuela ;

Di Rienzo, Martina ;

Piacentini, Mauro ;

Fimia, Gian Maria .

TRENDS IN BIOCHEMICAL SCIENCES, 2017, 42 (01) :28-41

[2] Basic Science of Pulmonary Arterial Hypertension for Clinicians New Concepts and Experimental Therapies [J].

Archer, Stephen L. ;

Weir, E. Kenneth ;

Wilkins, Martin R. .

CIRCULATION, 2010, 121 (18) :2045-U175

[3] Impairment of autophagy in endothelial cells prevents shear-stress-induced increases in nitric oxide bioavailability [J].

Bharath, Leena P. ;

Mueller, Robert ;

Li, Youyou ;

Ruan, Ting ;

Kunz, David ;

Goodrich, Rebekah ;

Mills, Tyler ;

Deeter, Lance ;

Sargsyan, Ashot ;

Babu, Pon Velayutham Anandh ;

Graham, Timothy E. ;

Symons, J. David .

CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 2014, 92 (07) :605-612

[4] Uncoupling proteins 2 and 3 - Potential regulators of mitochondrial energy metabolism [J].

Boss, O ;

Hagen, T ;

Lowell, BB .

DIABETES, 2000, 49 (02) :143-156

[5] Hypoxia-induced autophagy in endothelial cells: a double-edged sword in the progression of infantile haemangioma? [J].

Chen, Gang ;

Zhang, Wei ;

Li, Yin-Ping ;

Ren, Jian-Gang ;

Xu, Ning ;

Liu, Hui ;

Wang, Feng-Qin ;

Sun, Zhi-Jun ;

Jia, Jun ;

Zhao, Yi-Fang .

CARDIOVASCULAR RESEARCH, 2013, 98 (03) :437-448

[6] Enhanced autophagy in pulmonary endothelial cells on exposure to HIV-Tat and morphine: Role in HIV-related pulmonary arterial hypertension [J].

Dalvi, Pranjali ;

Sharma, Himanshu ;

Chinnappan, Mahendran ;

Sanderson, Miles ;

Allen, Julie ;

Zeng, Ruoxi ;

Choi, Augustine ;

O'Brien-Ladner, Amy ;

Dhillon, Navneet K. .

AUTOPHAGY, 2016, 12 (12) :2420-2438

[7] Autophagy in Vascular Disease [J].

De Meyer, Guido R. Y. ;

Grootaert, Mandy O. J. ;

Michiels, Cederic F. ;

Kurdi, Ammar ;

Schrijvers, Dorien M. ;

Martinet, Wim .

CIRCULATION RESEARCH, 2015, 116 (03) :468-479

[8] The role of tissue factor and autophagy in pulmonary vascular remodeling in a rat model for chronic thromboembolic pulmonary hypertension [J].

Deng, Chaosheng ;

Wu, Dawen ;

Yang, Minxia ;

Chen, Yunfei ;

Ding, Haibo ;

Zhong, Zhanghua ;

Lian, Ningfang ;

Zhang, Qiaoxian ;

Wu, Shuang ;

Liu, Kaixiong .

RESPIRATORY RESEARCH, 2016, 17

[9] Altered mTOR and Beclin-1 mediated autophagic activation during right ventricular remodeling in monocrotaline-induced pulmonary hypertension [J].

Deng, Yan ;

Wu, Weifeng ;

Guo, Shenglan ;

Chen, Yuming ;

Liu, Chang ;

Gao, Xingcui ;

Wei, Bin .

RESPIRATORY RESEARCH, 2017, 18

[10] Cancer stem cell metabolism: a potential target for cancer therapy [J].

Deshmukh, Abhijeet ;

Deshpande, Kedar ;

Arfuso, Frank ;

Newsholme, Philip ;

Dharmarajan, Arun .

MOLECULAR CANCER, 2016, 15

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