Environmental Canalization of Life Span and Gene Expression in Caenorhabditis elegans

被引:10
|
作者
Mendenhall, Alexander [1 ]
Crane, Matthew M. [1 ]
Leiser, Scott [2 ]
Sutphin, George [1 ]
Tedesco, Patricia M. [3 ]
Kaeberlein, Matt [1 ]
Johnson, Thomas E. [3 ,4 ,5 ]
Brent, Roger [6 ]
机构
[1] Univ Washington, Dept Pathol, Seattle, WA 98195 USA
[2] Univ Michigan, Dept Mol & Integrat Physiol, Ann Arbor, MI 48109 USA
[3] Univ Colorado, Inst Behav Genet, Boulder, CO 80309 USA
[4] Univ Colorado, Dept Integrat Physiol, Boulder, CO 80309 USA
[5] Univ Colorado, Biofrontiers Inst, Boulder, CO 80309 USA
[6] Fred Hutchinson Canc Res Ctr, Div Basic Sci, 1124 Columbia St, Seattle, WA 98104 USA
来源
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES | 2017年 / 72卷 / 08期
基金
美国国家卫生研究院;
关键词
Variation; Biomarker; Aging; Nongenetic; Proteostasis; HEAT-SHOCK; TEMPERATURE; LONGEVITY; VARIABILITY; DURATION; PROTEIN; HSF-1; COLD; CELL;
D O I
10.1093/gerona/glx017
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Animals, particularly poikilotherms, exhibit distinct physiologies at different environmental temperatures. Here, we hypothesized that temperature-based differences in physiology could affect the amount of variation in complex quantitative traits. Specifically, we examined, in Caenorhabditis elegans, how different temperatures (15 degrees C, 20 degrees C, and 25 degrees C) affected the amount of interindividual variation in life span and also expression of three reporter genes-transcriptional reporters for vit-2, gpd-2, and hsp-16.2 (a life-span biomarker). We found the expected inverse relationship between temperature and average life span. Surprisingly, we found that at the highest temperature, there were fewer differences between individuals in life span and less interindividual variation in expression of all three reporters. We suggest that growth at 25 degrees C might canalize (reduce interindividual differences in) life span and expression of some genes by eliciting a small constitutive heat shock response. Growth at 25 degrees C requires wild-type hsf-1, which encodes the main heat shock response transcriptional activator. We speculate that increased chaperone activity at 25 degrees C may reduce interindividual variation in gene expression by increasing protein folding efficiency. We hypothesize that reduced variation in gene expression may ultimately cause reduced variation in life span.
引用
收藏
页码:1033 / 1037
页数:5
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