Snake venom neutralization by Indian medicinal plants (Vitex negundo and Emblica officinalis) root extracts

被引：126
作者：
Alam, MI [1 ]
Gomes, A
机构：
[1] Acharya Shri Chander Coll Med Sci & Hosp, Dept Physiol, Jammu 180006, India
[2] Univ Calcutta, Dept Physiol, Kolkata 700009, W Bengal, India
来源：
JOURNAL OF ETHNOPHARMACOLOGY | 2003年 / 86卷 / 01期
关键词：
antisnake venom activity; anti-inflammatory; Vipera russellii; Vitex negundo; Emblica officinalis;
D O I：
10.1016/S0378-8741(03)00049-7
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
The methanolic root extracts of Vitex negundo Linn. and Emblica officinalis Gaertn. were explored for the first time for antisnake venom activity. The plant (V negundo and E. officinalis) extracts significantly antagonized the Vipera russellii and Naja kaouthia venom induced lethal activity both in in vitro and in vivo studies. V russellii venom-induced haemorrhage, coagulant, defibrinogenating and inflammatory activity was significantly neutralized by both plant extracts. No precipitating bands were observed between the plant extract and snake venom. The above observations confirmed that the plant extracts possess potent snake venom neutralizing capacity and need further investigation. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.
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收藏
页码：75 / 80
页数：6
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