Impact of tumor microenvironment composition on therapeutic responses and clinical outcomes in cancer

被引：44
作者：
Anari, Fern [1 ]
Ramamurthy, Chethan [1 ]
Zibelman, Matthew [1 ]
机构：
[1] Fox Chase Canc Ctr Temple Hlth, Philadelphia, PA USA
来源：
FUTURE ONCOLOGY | 2018年 / 14卷 / 14期
关键词：
biomarkers; immunotherapy; molecular oncology; oncogenes; REGULATORY T-CELLS; INDOLEAMINE 2,3-DIOXYGENASE EXPRESSION; PHASE-II TRIAL; INTERFERON-ALPHA; TRYPTOPHAN CATABOLISM; METASTATIC MELANOMA; PANCREATIC-CANCER; DOUBLE-BLIND; INTERLEUKIN-2; FIBROBLASTS;
D O I：
10.2217/fon-2017-0585
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The tumor microenvironment (TME) plays an important role in cancer growth and progression. Paradoxically, the TME is capable of acting as both a potential barrier and facilitator of tumor proliferation by affecting various processes including local growth resistance, immune system interactions, and the formation of distant metastases. This important interaction between cancer cells and their local environment, composed of immune cells, angiogenic cells, lymphatic endothelial cells and cancer-associated fibroblasts is paramount to determine a cancer cell's ability to grow and ultimately metastasize. It is essential to understand this complex interplay in order to define treatment modalities to target the TME as part of anti-cancer therapy. [GRAPHICS]
引用
收藏
页码：1409 / 1421
页数：13
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