Molecular Iodine-Mediated Difunctionalization of Alkenes with Nitriles and Thiols Leading to β-Acetamido Sulfides

被引：97
作者：
Cui, Huanhuan
Liu, Xiaoxia
Wei, Wei [1 ]
Yang, Daoshan
He, Chenglong
Zhang, Tiantian
Wang, Hua [1 ]
机构：
[1] Qufu Normal Univ, Sch Chem & Chem Engn, Key Lab Life Organ Anal, Qufu 273165, Shandong, Peoples R China
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2016年 / 81卷 / 06期
基金：
中国国家自然科学基金;
关键词：
CHARGE-TRANSFER COMPLEXES; ARYL SULFONYL HYDRAZIDES; METAL-FREE SYNTHESIS; ONE-POT SYNTHESIS; ANCHIMERIC ASSISTANCE; SUBSTITUTION-REACTION; AMINO-ALKENES; DIRECT ACCESS; DISULFIDES; SYSTEM;
D O I：
10.1021/acs.joc.5b02579
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A direct difunctionalization protocol of alkenes with nitriles and thiols toward beta-acetamido sulfide derivatives has been proposed under metal-free synthesis conditions. The present protocol provides the facile and highly efficient synthesis of various beta-acetamido sulfides in a scaled-up manner with good to excellent yields simply using inexpensive molecular iodine as a catalyst, DMSO as a mild oxidant, and readily available thiols as thiolating reagents.
引用
收藏
页码：2252 / 2260
页数：9
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