Programmed cell death-1 blockade in recurrent disseminated Ewing sarcoma

被引：30

作者：

McCaughan, Georgia J. B. ^{[3
]}

Fulham, Michael J. ^{[1
,3
]}

Mahar, Annabelle ^{[3
]}

Soper, Judy ^{[3
,4
]}

Hong, Angela M. ^{[1
,2
]}

Stalley, Paul D. ^{[3
]}

Tattersall, Martin H. N. ^{[1
,2
]}

Bhadri, Vivek A. ^{[1
,2
]}

机构：

[1] Univ Sydney, Sydney Med Sch, Sydney, NSW 2006, Australia

[2] Chris OBrien Lifehouse, 119-143 Missenden Rd, Camperdown, NSW 2050, Australia

[3] Royal Prince Alfred Hosp, Camperdown, NSW 2050, Australia

[4] Specialist Magnet Resonance Imaging, Newton, NSW, Australia

来源：

JOURNAL OF HEMATOLOGY & ONCOLOGY | 2016年 / 9卷

关键词：

Ewing sarcoma; Immunotherapy; Anti-programmed cell death-1 antibody; Case report; GENOMIC INSTABILITY; CANCER; SURVIVAL; EXPERIENCE; NIVOLUMAB; ANTIBODY; THERAPY; REPAIR; FAMILY; TUMORS;

D O I：

10.1186/s13045-016-0278-x

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: Ewing sarcoma (EWS) is a malignant tumour of bone and soft tissue, and although many patients are cured with conventional multimodal therapy, those with recurrent or metastatic disease have a poor prognosis. Genomic instability and programmed cell death ligand-1 (PD-L1) expression have been identified in EWS, providing a rationale for treatment with agents that block the programmed cell death-1 (PD-1) receptor. Case presentation: In this report, we describe a heavily pre-treated patient with recurrent metastatic EWS who achieved a clinical and radiological remission with PD-1 blockade. Conclusions: To our knowledge, this is the first reported case demonstrating efficacy of PD-1 blockade in EWS. This warrants further investigation in particular given the poor prognosis in patients with recurrent or metastatic disease.

引用

页数：5

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