Growth and aging: a common molecular mechanism

被引：178
作者：
Blagosklonny, Mikhail V. [1 ]
Hall, Michael N. [2 ]
机构：
[1] Roswell Pk Canc Inst, Buffalo, NY 14263 USA
[2] Univ Basel, Biozentrum, CH-4056 Basel, Switzerland
来源：
AGING-US | 2009年 / 1卷 / 04期
基金：
瑞士国家科学基金会;
关键词：
aging; growth; rapamycin; TOR; mitochondria; LIFE-SPAN EXTENSION; CALORIE RESTRICTION; CELLULAR SENESCENCE; INSULIN-RECEPTOR; SACCHAROMYCES-CEREVISIAE; REDUCED INCIDENCE; MAMMALIAN TARGET; UP-REGULATION; TOR; YEAST;
D O I：
10.18632/aging.100040
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
It is commonly assumed that growth and aging are somehow linked, but the nature of this link has been elusive. Here we review the aging process as a continuation of TOR-driven growth. TOR is absolutely essential for developmental growth, but upon completion of development it causes aging and age-related diseases. Thus, the nutrient-sensing and growth-promoting TOR signaling pathway may provide a molecular link between growth and aging that is universal from yeast to human.
引用
收藏
页码：357 / 362
页数：6
相关论文
共 71 条
  • [1] Up-regulation of phosphorylated/activated p70 S6 kinase and its relationship to neurofibrillary pathology in Alzheimer's disease
    An, WL
    Cowburn, RF
    Li, L
    Braak, H
    Alafuzoff, I
    Iqbal, K
    Iqbal, IG
    Winblad, B
    Pei, JJ
    [J]. AMERICAN JOURNAL OF PATHOLOGY, 2003, 163 (02) : 591 - 607
  • [2] PROLIFERATIVE POTENTIAL OF HUMAN-FIBROBLASTS - AN INVERSE DEPENDENCE ON CELL-SIZE
    ANGELLO, JC
    PENDERGRASS, WR
    NORWOOD, TH
    PROTHERO, J
    [J]. JOURNAL OF CELLULAR PHYSIOLOGY, 1987, 132 (01) : 125 - 130
  • [3] Austriaco NR, 1996, YEAST, V12, P623, DOI 10.1002/(SICI)1097-0061(19960615)12:7<623::AID-YEA968>3.0.CO
  • [4] 2-G
  • [5] Insulin and amino-acid regulation of mTOR signaling and kinase activity through the Rheb GTPase
    Avruch, J.
    Hara, K.
    Lin, Y.
    Liu, M.
    Long, X.
    Ortiz-Vega, S.
    Yonezawa, K.
    [J]. ONCOGENE, 2006, 25 (48) : 6361 - 6372
  • [6] Long-lived Klotho mice: new insights into the roles of IGF-1 and insulin-in aging
    Bartke, A
    [J]. TRENDS IN ENDOCRINOLOGY AND METABOLISM, 2006, 17 (02) : 33 - 35
  • [7] Skeletal Muscle-Specific Ablation of raptor, but Not of rictor, Causes Metabolic Changes and Results in Muscle Dystrophy
    Bentzinger, C. Florian
    Romanino, Klaas
    Cloetta, Dimitri
    Lin, Shuo
    Mascarenhas, Joseph B.
    Oliveri, Filippo
    Xia, Jinyu
    Casanova, Emilio
    Costa, Celine F.
    Brink, Marijke
    Zorzato, Francesco
    Hall, Michael N.
    Rueegg, Markus A.
    [J]. CELL METABOLISM, 2008, 8 (05) : 411 - 424
  • [8] Rapamycin alleviates toxicity of different aggregate-prone proteins
    Berger, Z
    Ravikumar, B
    Menzies, FM
    Oroz, LG
    Underwood, BR
    Pangalos, MN
    Schmitt, I
    Wullner, U
    Evert, BO
    O'Kane, CJ
    Rubinsztein, DC
    [J]. HUMAN MOLECULAR GENETICS, 2006, 15 (03) : 433 - 442
  • [9] Bilinski T, 2006, ACTA BIOCHIM POL, V53, P833
  • [10] Aging and immortality - Quasi-programmed senescence and its pharmacologic inhibition
    Blagosklonny, Mikhail V.
    [J]. CELL CYCLE, 2006, 5 (18) : 2087 - 2102
12345678