Anti-inflammatory eunicellin-based diterpenoids from the cultured soft coral Klyxum simplex

被引：49

作者：

Chen, Bo-Wei ^{[1
]}

Chao, Chih-Hua ^{[1
]}

Su, Jui-Hsin ^{[2
]}

Wen, Zhi-Hong ^{[1
]}

Sung, Ping-Jyun ^{[3
]}

Sheu, Jyh-Horng ^{[1
,4
]}

机构：

[1] Natl Sun Yat Sen Univ, Dept Marine Biotechnol & Resources, Kaohsiung 804, Taiwan

[2] Mei Ho Inst Technol, Dept Biol Sci & Technol, Nei Pu Hsiang 912, Pingtung, Taiwan

[3] Natl Museum Marine Biol & Aquarium, Taiwan Coral Res Ctr, Checheng 944, Pingtung, Taiwan

[4] Natl Sun Yat Sen Univ, Asia Pacific Ocean Res Ctr, Kaohsiung 804, Taiwan

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2010年 / 8卷 / 10期

关键词：

BIOACTIVE TERPENOIDS; LIPOPOLYSACCHARIDE; OCTOCORALLIA;

D O I：

10.1039/b926353e

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Three novel eunicellin-based diterpenoids, namely klysimplexin sulfoxides A-C (1-3), were isolated from the cultured soft coral Klyxum simplex. Their structures were elucidated by spectroscopic methods, particularly 1D and 2D-NMR experiments. Compounds 1-3 significantly inhibited the accumulation of the pro-inflammatory iNOS protein in LPS-stimulated RAW264.7 macrophage cells. Compound 3 also showed marked activity in inhibiting the expression of COX-2 protein in the same cells.

引用

页码：2363 / 2366

页数：4

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