Organocatalytic Michael addition of unprotected 3-substituted oxindoles to nitroolefins

被引：70

作者：

Ding, Miao ^{[1
]}

Zhou, Feng ^{[1
]}

Qian, Zi-Qing ^{[1
]}

Zhou, Jian ^{[1
]}

机构：

[1] E China Normal Univ, Shanghai Key Lab Green Chem & Chem Proc, Dept Chem, Shanghai 200062, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2010年 / 8卷 / 13期

关键词：

FRIEDEL-CRAFTS ALKYLATION; CATALYTIC ASYMMETRIC-SYNTHESIS; QUATERNARY STEREOGENIC CENTERS; ENANTIOSELECTIVE SYNTHESIS; CONJUGATE ADDITION; CARBENE LIGANDS; ALPHA-ARYLATION; THIOUREA; NITROALKENES; CONSTRUCTION;

D O I：

10.1039/c004037a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Quinidine was found to catalyze the Michael addition of unprotected 3-substituted oxindoles to nitroolefins in excellent yield and moderate to good diastereoselectivity. Bifunctional quinidine derived thiourea catalyst 10 could catalyze this reaction to afford the major diastereomer in up to 85% ee.

引用

页码：2912 / 2914

页数：3

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