PINK1/PRKN-dependent mitophagy in the burn injury model

被引：4
|
作者：
Zhao, Wenli [1 ]
Han, Juntao [1 ]
Hu, Xuehui [2 ]
Zhou, Qin [1 ]
Qi, Rui [3 ]
Sun, Wen [4 ]
Liu, Lingling [5 ]
机构：
[1] Air Force Med Univ, Affiliated Hosp 1, Dept Burns & Cutaneous Surg, Xian 710032, Peoples R China
[2] Air Force Med Univ, Affiliated Hosp 1, Dept Nursing, Changle West Rd, Xian 710032, Peoples R China
[3] Air Force Med Univ, Affiliated Hosp 1, Dept Endocrinol & Metab, Xian 710032, Peoples R China
[4] Air Force Med Univ, Affiliated Hosp 1, Hepatobiliary Splen Pancreat Surg, Xian 710032, Peoples R China
[5] Air Force Med Univ, Affiliated Hosp 1, Dept Outpatient, Xian 710032, Peoples R China
来源：
BURNS | 2021年 / 47卷 / 03期
关键词：
Mitophagy; Burn injury; PINK1; PRKN; Mitochondria damage; MITOCHONDRIAL DYSFUNCTION; PROTEIN; PINK1; MUTATIONS; MEMBRANE; REVEALS; PARKIN;
D O I：
10.1016/j.burns.2020.07.026
中图分类号：
R4 [临床医学];
学科分类号：
1002 ; 100602 ;
摘要：
Burn injury leads to mitochondrial dysfunction and autophagy, also known as mitophagy. The alleviation of mitochondrial damage may be a potential method for the treatment of burn injury and complications. In this animal study, we analyzed the expression of mitochondrial damage-and mitophagy-related factors, specifically PINK1 and PRKN. The results showed mitochondria damage in the skin; compared with the normal control group, genes involved in the mitochondrial damage, such as Nrf-1, UQCRC2, CYC1, and NDUFA9, as well as in the mitophagy, including PINK1, PRKN, MFN1, and USP30, were differentially expressed. Furthermore, PINK1 interacted with PRKN and participated in mitophagy in the skin. In conclusion, our data reveal more about the mechanism underlying mitophagy in burns, providing a potential clinical treatment. (c) 2020 Elsevier Ltd and ISBI. All rights reserved.
引用
收藏
页码：628 / 633
页数：6
相关论文
共 50 条
  • [11] Reassessing kinetin's effect on PINK1 and mitophagy
    Gan, Zhong Yan
    Komander, David
    Callegari, Sylvie
    AUTOPHAGY, 2024, 20 (11) : 2596 - 2597
  • [12] The mitochondrial kinase PINK1: functions beyond mitophagy
    Voigt, Aaron
    Berlemann, Lena A.
    Winklhofer, Konstanze F.
    JOURNAL OF NEUROCHEMISTRY, 2016, 139 : 232 - 239
  • [13] Cytosolic cleaved PINK1 represses Parkin translocation to mitochondria and mitophagy
    Fedorowicz, Maja A.
    de Vries-Schneider, Rosa L. A.
    Rueb, Cornelia
    Becker, Dorothea
    Huang, Yong
    Zhou, Chun
    Wolken, Dana M. Alessi
    Voos, Wolfgang
    Liu, Yuhui
    Przedborski, Serge
    EMBO REPORTS, 2014, 15 (01) : 86 - 93
  • [14] PRKN, DJ-1, and PINK1 Screening Identifies Novel Splice Site Mutation in PRKN and Two Novel DJ-1 Mutations
    Ghazavi, Farzaneh
    Fazlali, Zeinab
    Banihosseini, Setareh Sadat
    Hosseini, Sayed-Rzgar
    Kazemi, Mohammad Hossein
    Shojaee, Seyedmehdi
    Parsa, Khosro
    Sadeghi, Homa
    Sina, Farzad
    Rohani, Mohammad
    Shahidi, Gholam-Ali
    Ghaemi, Nasser
    Ronaghi, Mostafa
    Elahi, Elahe
    MOVEMENT DISORDERS, 2011, 26 (01) : 80 - 89
  • [15] Spautin-1 promotes PINK1-PRKN-dependent mitophagy and improves associative learning capability in an alzheimer disease animal model
    Yi, Juan
    Wang, He-Ling
    Lu, Guang
    Zhang, Hailong
    Wang, Lina
    Li, Zhen-Yu
    Wang, Liming
    Wu, Yihua
    Xia, Dajing
    Fang, Evandro F.
    Shen, Han-Ming
    AUTOPHAGY, 2024, 20 (12) : 2655 - 2676
  • [16] RNA-binding protein YBX1 promotes brown adipogenesis and thermogenesis via PINK1/PRKN-mediated mitophagy
    Wu, Ruifan
    Cao, Shuting
    Li, Fan
    Feng, Shengchun
    Shu, Gang
    Wang, Lina
    Gao, Ping
    Zhu, Xiaotong
    Zhu, Canjun
    Wang, Songbo
    Jiang, Qingyan
    FASEB JOURNAL, 2022, 36 (03)
  • [17] LACTB2 renders radioresistance by activating PINK1/Parkin-dependent mitophagy in nasopharyngeal carcinoma
    Chen, Qianping
    Zheng, Wang
    Zhu, Lin
    Liu, Hongxia
    Song, Yimeng
    Hu, Songling
    Bai, Yang
    Pan, Yan
    Zhang, Jianghong
    Guan, Jian
    Shao, Chunlin
    CANCER LETTERS, 2021, 518 : 127 - 139
  • [18] PINK1 is recruited to mitochondria with parkin and associates with LC3 in mitophagy
    Kawajiri, Sumihiro
    Saiki, Shinji
    Sato, Shigeto
    Sato, Fumiaki
    Hatano, Taku
    Eguchi, Hiroto
    Hattori, Nobutaka
    FEBS LETTERS, 2010, 584 (06) : 1073 - 1079
  • [19] Lead (Pb) induced ATM-dependent mitophagy via PINK1/Parkin pathway
    Gu, Xueyan
    Qi, Yongmei
    Feng, Zengxiu
    Ma, Lin
    Gao, Ke
    Zhang, Yingmei
    TOXICOLOGY LETTERS, 2018, 291 : 92 - 100
  • [20] BAG6 promotes PINK1 signaling pathway and is essential for mitophagy
    Ragimbeau, Romain
    El Kebriti, Leila
    Sebti, Salwa
    Fourgous, Elise
    Boulahtouf, Abdelhay
    Arena, Giuseppe
    Espert, Lucile
    Turtoi, Andrei
    Gongora, Celine
    Houede, Nadine
    Pattingre, Sophie
    FASEB JOURNAL, 2021, 35 (02)
12345