PINK1/PRKN-dependent mitophagy in the burn injury model

被引：4
|
作者：
Zhao, Wenli [1 ]
Han, Juntao [1 ]
Hu, Xuehui [2 ]
Zhou, Qin [1 ]
Qi, Rui [3 ]
Sun, Wen [4 ]
Liu, Lingling [5 ]
机构：
[1] Air Force Med Univ, Affiliated Hosp 1, Dept Burns & Cutaneous Surg, Xian 710032, Peoples R China
[2] Air Force Med Univ, Affiliated Hosp 1, Dept Nursing, Changle West Rd, Xian 710032, Peoples R China
[3] Air Force Med Univ, Affiliated Hosp 1, Dept Endocrinol & Metab, Xian 710032, Peoples R China
[4] Air Force Med Univ, Affiliated Hosp 1, Hepatobiliary Splen Pancreat Surg, Xian 710032, Peoples R China
[5] Air Force Med Univ, Affiliated Hosp 1, Dept Outpatient, Xian 710032, Peoples R China
来源：
BURNS | 2021年 / 47卷 / 03期
关键词：
Mitophagy; Burn injury; PINK1; PRKN; Mitochondria damage; MITOCHONDRIAL DYSFUNCTION; PROTEIN; PINK1; MUTATIONS; MEMBRANE; REVEALS; PARKIN;
D O I：
10.1016/j.burns.2020.07.026
中图分类号：
R4 [临床医学];
学科分类号：
1002 ; 100602 ;
摘要：
Burn injury leads to mitochondrial dysfunction and autophagy, also known as mitophagy. The alleviation of mitochondrial damage may be a potential method for the treatment of burn injury and complications. In this animal study, we analyzed the expression of mitochondrial damage-and mitophagy-related factors, specifically PINK1 and PRKN. The results showed mitochondria damage in the skin; compared with the normal control group, genes involved in the mitochondrial damage, such as Nrf-1, UQCRC2, CYC1, and NDUFA9, as well as in the mitophagy, including PINK1, PRKN, MFN1, and USP30, were differentially expressed. Furthermore, PINK1 interacted with PRKN and participated in mitophagy in the skin. In conclusion, our data reveal more about the mechanism underlying mitophagy in burns, providing a potential clinical treatment. (c) 2020 Elsevier Ltd and ISBI. All rights reserved.
引用
收藏
页码：628 / 633
页数：6
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