The μ-opioid receptor induces miR-21 expression and is ERK/PKCμ-dependent

被引：2

作者：

Chang, Jen-Kuan ^{[1
]}

Cornwell, William D. ^{[1
]}

Rogers, Thomas J. ^{[1
]}

机构：

[1] Temple Univ, Lewis Katz Sch Med, Ctr Inflammat Translat & Clin Lung Res, 3500 N Broad St, Philadelphia, PA 19122 USA

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2021年 / 356卷

基金：

美国国家卫生研究院;

关键词：

Monocyte; PKD; PKC mu; microRNA; MiR-21; ACTIVATED PROTEIN-KINASE; NF-KAPPA-B; MICRORNA EXPRESSION; IN-VIVO; INFLAMMATION; INHIBITION; CELLS; PTEN; MACROPHAGES; RELEASE;

D O I：

10.1016/j.jneuroim.2021.577585

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Micro RNA-21 (miR-21) is believed to perform an important role in the transition from inflammation to resolution in the innate immune response. The biochemical basis for the induction of miR-21 remains uncertain. However, the activation of the mu-opioid receptor (MOR) induces the expression of miR-21. Our results show that human monocytes treated with mu-opioid agonists exhibit a significant increase in miR-21 expression. We found that MOR-induction of miR-21 requires the activation of the Ras-Raf-MEK-ERK signaling cascade, and to our surprise, the activation of PKC mu (PKD1). These results are significant given the role of miR-21 in the sensitivity to pain.

引用

页数：7

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