Telomerase activity in B and T lymphocytes of patients with systemic lupus erythematosus

被引：24
作者：
Klapper, W
Moosig, F
Sotnikova, A
Qian, W
Schröder, JO
Parwaresch, R
机构：
[1] Univ Kiel, Dept Haematol, D-24105 Kiel, Germany
[2] Univ Kiel, Lymph Node Registry Kiel, D-24105 Kiel, Germany
[3] Univ Kiel, Dept Internal Med 2, D-24107 Kiel, Germany
[4] Zhejiang Univ, Affiliated Hosp 1, Dept Haematol, Hangzhou 310003, Peoples R China
来源：
ANNALS OF THE RHEUMATIC DISEASES | 2004年 / 63卷 / 12期
关键词：
D O I：
10.1136/ard.2003.016022
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Objective: To evaluate telomerase activity as a marker of lymphocyte proliferation in systemic lupus erythematosus (SLE). Methods: CD19+, CD4+, and CD8+ lymphocytes were isolated from the peripheral blood of nine patients with SLE and nine healthy controls by means of magnetic bead-coupled antibodies and tested for telomerase activity with the TRAP assay. Results: Telomerase activity was significantly increased in CD19+ B cells from patients with SLE. CD4+ and CD8+ T cells from lupus patients displayed increased mean telomerase activity, although the difference from normal controls did not reach statistical significance. Conclusions: Increased telomerase activity in the B and the T cell lineage might indicate activation and proliferation of these lymphocytes.
引用
收藏
页码：1681 / 1683
页数：3
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