Telomerase activity in B and T lymphocytes of patients with systemic lupus erythematosus

被引：24

作者：

Klapper, W

Moosig, F

Sotnikova, A

Qian, W

Schröder, JO

Parwaresch, R

机构：

[1] Univ Kiel, Dept Haematol, D-24105 Kiel, Germany

[2] Univ Kiel, Lymph Node Registry Kiel, D-24105 Kiel, Germany

[3] Univ Kiel, Dept Internal Med 2, D-24107 Kiel, Germany

[4] Zhejiang Univ, Affiliated Hosp 1, Dept Haematol, Hangzhou 310003, Peoples R China

来源：

ANNALS OF THE RHEUMATIC DISEASES | 2004年 / 63卷 / 12期

关键词：

D O I：

10.1136/ard.2003.016022

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective: To evaluate telomerase activity as a marker of lymphocyte proliferation in systemic lupus erythematosus (SLE). Methods: CD19+, CD4+, and CD8+ lymphocytes were isolated from the peripheral blood of nine patients with SLE and nine healthy controls by means of magnetic bead-coupled antibodies and tested for telomerase activity with the TRAP assay. Results: Telomerase activity was significantly increased in CD19+ B cells from patients with SLE. CD4+ and CD8+ T cells from lupus patients displayed increased mean telomerase activity, although the difference from normal controls did not reach statistical significance. Conclusions: Increased telomerase activity in the B and the T cell lineage might indicate activation and proliferation of these lymphocytes.

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收藏

页码：1681 / 1683

页数：3

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