Cancer: Context Is Key for E-cadherin in Invasion and Metastasis

被引：9
|
作者：
Fearon, Eric R. [1 ,2 ,3 ,4 ]
机构：
[1] Univ Michigan, Sch Med, Rogel Canc Ctr, Ann Arbor, MI 48109 USA
[2] Univ Michigan, Sch Med, Dept Internal Med, Ann Arbor, MI 48109 USA
[3] Univ Michigan, Sch Med, Dept Human Genet, Ann Arbor, MI 48109 USA
[4] Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA
来源：
CURRENT BIOLOGY | 2019年 / 29卷 / 21期
关键词：
BREAST-CANCER; EXPRESSION; GENOME;
D O I：
10.1016/j.cub.2019.09.054
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A recent paper demonstrates how tissue context impacts the breast cancer cell phenotype. Loss of the E-cadherin tumor suppressor protein enhanced cell invasion, but inhibited multiple steps in metastatic spread due to the accumulation of reactive oxygen species and induction of apoptosis.
引用
收藏
页码：R1140 / R1142
页数：4
相关论文
共 50 条
  • [1] The E-cadherin/catenin complex in invasion and metastasis
    Bracke, ME
    VanRoy, FM
    Mareel, MM
    ATTEMPTS TO UNDERSTAND METASTASIS FORMATION I: METASTASIS-RELATED MOLECULES, 1996, 213 : 123 - 161
  • [2] E-cadherin and its associated protein catenins, cancer invasion and metastasis
    Jiang, WG
    BRITISH JOURNAL OF SURGERY, 1996, 83 (04) : 437 - 446
  • [3] Expression of E-cadherin and α-catenin in patients with colorectal carcinoma -: Correlation with cancer invasion and metastasis
    Gofuku, J
    Shiozaki, H
    Tsujinaka, T
    Inoue, M
    Tamura, S
    Doki, Y
    Matsui, S
    Tsukita, S
    Kikkawa, N
    Monden, M
    AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 1999, 111 (01) : 29 - 37
  • [4] E-cadherin is an invasion suppressor and metastasis promoter in multiple models of breast cancer.
    Padmanaban, V.
    Ewald, A. J.
    MOLECULAR BIOLOGY OF THE CELL, 2018, 29 (26)
  • [5] E-CADHERIN AS AN INVASION SUPPRESSOR
    BIRCHMEIER, W
    HULSKEN, J
    BEHRENS, J
    CELL ADHESION AND HUMAN DISEASE, 1995, 189 : 124 - 141
  • [6] EXPRESSION OF E-CADHERIN IN EMBRYOGENETIC INGRESSION AND CANCER INVASION
    MAREEL, M
    BRACKE, M
    VANROY, F
    VAKAET, L
    INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY, 1993, 37 (01): : 227 - 235
  • [7] Dual roles of E-cadherin in prostate cancer invasion
    Chunthapong, J
    Seftor, EA
    Khalkhali-Ellis, Z
    Seftor, REB
    Amir, S
    Lubaroff, DM
    Heidger, PM
    Hendrix, MJC
    JOURNAL OF CELLULAR BIOCHEMISTRY, 2004, 91 (04) : 649 - 661
  • [8] E-CADHERIN EXPRESSION - A COUNTERBALANCE FOR CANCER CELL INVASION
    MAREEL, M
    VLEMINCKX, K
    VERMEULEN, S
    BRACKE, M
    VANROY, F
    BULLETIN DU CANCER, 1992, 79 (04) : 347 - 355
  • [9] Invasion and metastasis of oral cancer cells require methylation of E-cadherin and/or degradation of membranous β-catenin
    Kudo, Y
    Kitajima, S
    Ogawa, I
    Hiraoka, M
    Sargolzaei, S
    Keikhaee, MR
    Sato, S
    Miyauchi, M
    Takata, T
    CLINICAL CANCER RESEARCH, 2004, 10 (16) : 5455 - 5463
  • [10] SLUG promotes invasion and metastasis of anaplastic thyroid cancer cells through repression of E-cadherin
    Sun, Wenhai
    Yang, Shouxiang
    Ma, Qing
    Zheng, Shuyun
    Wang, Jigang
    Chen, Dong
    Zhang, Kejun
    INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY, 2016, 9 (08): : 8373 - 8379
12345