Cancer: Context Is Key for E-cadherin in Invasion and Metastasis

被引：11
作者：
Fearon, Eric R. [1 ,2 ,3 ,4 ]
机构：
[1] Univ Michigan, Sch Med, Rogel Canc Ctr, Ann Arbor, MI 48109 USA
[2] Univ Michigan, Sch Med, Dept Internal Med, Ann Arbor, MI 48109 USA
[3] Univ Michigan, Sch Med, Dept Human Genet, Ann Arbor, MI 48109 USA
[4] Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA
来源：
CURRENT BIOLOGY | 2019年 / 29卷 / 21期
关键词：
BREAST-CANCER; EXPRESSION; GENOME;
D O I：
10.1016/j.cub.2019.09.054
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A recent paper demonstrates how tissue context impacts the breast cancer cell phenotype. Loss of the E-cadherin tumor suppressor protein enhanced cell invasion, but inhibited multiple steps in metastatic spread due to the accumulation of reactive oxygen species and induction of apoptosis.
引用
收藏
页码：R1140 / R1142
页数：4
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