Association between polymorphisms in the vitamin D receptor and susceptibility to multiple sclerosis

被引:18
作者
Cancela Diez, Barbara [1 ]
Perez-Ramirez, Cristina [2 ]
del Mar Maldonado-Montoro, Maria [3 ]
Isabel Carrasco-Campos, Maria [1 ]
Sanchez Martin, Almudena [1 ]
Pineda Lancheros, Laura Elena [1 ]
Martinez-Martinez, Fernando [4 ]
Angel Calleja-Hernandez, Miguel [2 ]
Carmen Ramirez-Tortosa, Maria [5 ]
Jimenez-Morales, Alberto [1 ]
机构
[1] Univ Hosp Virgen de las Nieves, Pharm Serv Pharmacogenet Unit, UGC Prov Farm Granada, Avda Fuerzas Armadas, Granada, Spain
[2] Univ Hosp Virgen Macarena, Pharm Serv Pharmacogenet Unit, Seville, Spain
[3] Hosp Campus Salud, Clin Anal Serv, Av Invest S-N, Granada 18016, Spain
[4] Univ Granada, Dept Pharm & Pharmaceut Technol, Social & Legal Assistance Pharm Sect, Fac Pharm, Campus Univ Cartuja S-N, Granada 18071, Spain
[5] Univ Granada, Fac Pharm, Dept Biochem, Campus Univ Cartuja S-N, Granada 18071, Spain
关键词
multiple sclerosis; polymorphisms; risk; VDR gene; CD4(+) T-CELLS; 25-HYDROXYVITAMIN D; GENE POLYMORPHISMS; D METABOLISM; RHEUMATOID-ARTHRITIS; LOW-PREVALENCE; RELAPSE RISK; DISABILITY; INTERLEUKIN-2; TRANSCRIPTION;
D O I
10.1097/FPC.0000000000000420
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Objectives Multiple sclerosis (MS) is a neurodegenerative chronic inflammatory. Mutations in the vitamin D receptor (VDR) gene can substantially affect serum vitamin D levels or alter its functionality, and can consequently increase susceptibility to developing MS. The objective of this study was to evaluate the association between polymorphisms in the VDR gene and risk of MS in a (Spanish) Caucasian population. Patients and methods We conducted a retrospective case-control study comprising 209 patients with relapsing-remitting multiple sclerosis (RRMS) and 836 controls of Caucasian origin from southern Spain. The ApaI (rs7975232), BsmI (rs1544410), Cdx2 (rs11568820), FokI (rs2228570), and TaqI (rs731236) gene polymorphisms were determined by allelic discrimination real-time PCR using TaqMan probes. Results The recessive logical regression model, adjusted for age and sex, revealed that the TT genotype for VDR FokI (rs2228570) polymorphism was associated with higher risk of MS (P = 0.0150; OR = 1.82; 95% CI = 1.12-2.94; TT vs. CT + CC). No association between the other polymorphisms and development of MS was found in any of the models analyzed. The haplotype analysis, adjusted for age, smoking, and sex, did not find any statistically significant association between the haplotypes analyzed and risk of MS. Conclusions The VDR FokI (rs2228570) polymorphism was significantly associated with developing MS. We found no influence of the ApaI (rs7975232), BsmI (rs1544410), Cdx2 (rs11568820), FokI (rs2228570), and TaqI (rs731236) gene polymorphisms on the risk of developing MS in our patients.
引用
收藏
页码:40 / 47
页数:8
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