Enantioselective Organocatalytic Conjugate Addition of Aromatic Ketones to Nitrodienes

被引：38

作者：

He, Tianxiong

Qian, Jing-Ying

Song, Hong-Liang

Wu, Xin-Yan ^{[1
]}

机构：

[1] E China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China

来源：

SYNLETT | 2009年 / 19期

基金：

中国国家自然科学基金;

关键词：

organic asymmetric catalysis; aromatic ketones; nitro-Michael additions; nitrodiene; chiral bifunctional thiourea; DIRECT MICHAEL ADDITION; ASYMMETRIC MICHAEL; BIFUNCTIONAL ORGANOCATALYSTS; NITROALKENES; ALDEHYDES; CATALYST;

D O I：

10.1055/s-0029-12183

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The organocatalytic asymmetric nitro-Michael addition of aromatic ketones to nitrodiene using various chiral primary amine thioureas was described. In the presence of 30 mol% of N-[(1R,2R)-2-amino-1,2-diphenylethyl]-N'-benzylthiourea, the Michael adducts were obtained in good yields and excellent enantioselectivity (94-98% ee).

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收藏

页码：3195 / 3197

页数：3

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