Fibroblast activation protein in liver fibrosis

被引：50
作者：
Lay, Angelina J. [1 ,4 ]
Zhang, Hui E. [1 ,4 ]
McCaughan, Geoffrey W. [2 ,3 ,4 ]
Gorrell, Mark D. [1 ,4 ]
机构：
[1] Centenary Inst, Liver Enzymes Metab & Inflammat Program, Sydney, NSW 2050, Australia
[2] Centenary Inst, Liver Injury & Canc Program, Sydney, NSW 2050, Australia
[3] Royal Prince Alfred Hosp, AW Morrow Gastroenterol & Liver Ctr, Sydney, NSW 2050, Australia
[4] Univ Sydney, Fac Med & Hlth, Sydney, NSW 2006, Australia
来源：
FRONTIERS IN BIOSCIENCE-LANDMARK | 2019年 / 24卷
基金：
英国医学研究理事会;
关键词：
Fibroblast Activation Protein; Serine Protease; Hydrolase; Aminopeptidase; Dipeptidyl Peptidase; Prolyl Oligopeptidase; Fibrosis; Review; DIPEPTIDYL-PEPTIDASE-IV; EPITHELIAL-MESENCHYMAL TRANSITION; CARCINOMA-ASSOCIATED FIBROBLASTS; REACTIVE STROMAL FIBROBLASTS; GROWTH-FACTOR; 21; EXTRACELLULAR-MATRIX; SUBSTRATE-SPECIFICITY; REMODELING INTERFACE; CRYSTAL-STRUCTURE; MMP-2; EXPRESSION;
D O I：
10.2741/4706
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Fibroblast activation protein (FAP) belongs to the dipeptidyl peptidase IV (DPP4; CD26) gene family. Other related genes in this family of enzyme include DPP4, 8 and 9. The FAP serine protease has the rare property of both dipeptidyl peptidase and endopeptidase activities capable of cleaving the post-proline bond at two or more residues from the N-terminus. FAP is involved in a variety of biological processes but its expression in healthy tissues is low. In contrast, FAP is significantly elevated in pathological conditions such as at sites of tissue remodelling and repair. Its differential pattern of expression in diseases supports the emerging concept for FAP as a potential disease biomarker as well as a useful therapeutic target for drug intervention. This review summarizes the current knowledge of FAP, particularly its diagnostic and pathological significance in liver fibrosis.
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页码：1 / 17
页数：17
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