Fibroblast activation protein in liver fibrosis

被引：50
作者：
Lay, Angelina J. [1 ,4 ]
Zhang, Hui E. [1 ,4 ]
McCaughan, Geoffrey W. [2 ,3 ,4 ]
Gorrell, Mark D. [1 ,4 ]
机构：
[1] Centenary Inst, Liver Enzymes Metab & Inflammat Program, Sydney, NSW 2050, Australia
[2] Centenary Inst, Liver Injury & Canc Program, Sydney, NSW 2050, Australia
[3] Royal Prince Alfred Hosp, AW Morrow Gastroenterol & Liver Ctr, Sydney, NSW 2050, Australia
[4] Univ Sydney, Fac Med & Hlth, Sydney, NSW 2006, Australia
来源：
FRONTIERS IN BIOSCIENCE-LANDMARK | 2019年 / 24卷
基金：
英国医学研究理事会;
关键词：
Fibroblast Activation Protein; Serine Protease; Hydrolase; Aminopeptidase; Dipeptidyl Peptidase; Prolyl Oligopeptidase; Fibrosis; Review; DIPEPTIDYL-PEPTIDASE-IV; EPITHELIAL-MESENCHYMAL TRANSITION; CARCINOMA-ASSOCIATED FIBROBLASTS; REACTIVE STROMAL FIBROBLASTS; GROWTH-FACTOR; 21; EXTRACELLULAR-MATRIX; SUBSTRATE-SPECIFICITY; REMODELING INTERFACE; CRYSTAL-STRUCTURE; MMP-2; EXPRESSION;
D O I：
10.2741/4706
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Fibroblast activation protein (FAP) belongs to the dipeptidyl peptidase IV (DPP4; CD26) gene family. Other related genes in this family of enzyme include DPP4, 8 and 9. The FAP serine protease has the rare property of both dipeptidyl peptidase and endopeptidase activities capable of cleaving the post-proline bond at two or more residues from the N-terminus. FAP is involved in a variety of biological processes but its expression in healthy tissues is low. In contrast, FAP is significantly elevated in pathological conditions such as at sites of tissue remodelling and repair. Its differential pattern of expression in diseases supports the emerging concept for FAP as a potential disease biomarker as well as a useful therapeutic target for drug intervention. This review summarizes the current knowledge of FAP, particularly its diagnostic and pathological significance in liver fibrosis.
引用
收藏
页码：1 / 17
页数：17
相关论文
共 109 条
  • [1] Two highly conserved glutamic acid residues in the predicted β propeller domain of dipeptidyl peptidase IV are required for its enzyme activity
    Abbott, CA
    McCaughan, GW
    Gorrell, MD
    [J]. FEBS LETTERS, 1999, 458 (03): : 278 - 284
  • [2] Fibroblast activation protein:: a serine protease expressed at the remodeling interface in idiopathic pulmonary flbrosis
    Acharya, PS
    Zukas, A
    Chandan, V
    Katzenstein, ALA
    Puré, E
    [J]. HUMAN PATHOLOGY, 2006, 37 (03) : 352 - 360
  • [3] LY2405319, an Engineered FGF21 Variant, Improves the Metabolic Status of Diabetic Monkeys
    Adams, Andrew C.
    Halstead, Carolyn A.
    Hansen, Barbara C.
    Irizarry, Armando R.
    Martin, Jennifer A.
    Myers, Sharon R.
    Reynolds, Vincent L.
    Smith, Holly W.
    Wroblewski, Victor J.
    Kharitonenkov, Alexei
    [J]. PLOS ONE, 2013, 8 (06):
  • [4] Structural and kinetic analysis of the substrate specificity of human fibroblast activation protein α
    Aertgeerts, K
    Levin, I
    Shi, LH
    Snell, GP
    Jennings, A
    Prasad, GS
    Zhang, YM
    Kraus, ML
    Salakian, S
    Sridhar, V
    Wijnands, R
    Tennant, MG
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (20) : 19441 - 19444
  • [5] Crystal structure of human dipeptidyl peptidase IV in complex with a decapeptide reveals details on substrate specificity and tetrahedral intermediate formation
    Aertgeerts, K
    Ye, S
    Tennant, MG
    Kraus, ML
    Rogers, J
    Sang, BC
    Skene, RJ
    Webb, DR
    Prasad, GS
    [J]. PROTEIN SCIENCE, 2004, 13 (02) : 412 - 421
  • [6] N-linked glycosylation of dipeptidyl peptidase IV (CD26): Effects on enzyme activity, homodimer formation, and adenosine deaminase binding
    Aertgeerts, K
    Ye, S
    Shi, LH
    Prasad, SG
    Witmer, D
    Chi, E
    Sang, BC
    Wijnands, RA
    Webb, DR
    Swanson, RV
    [J]. PROTEIN SCIENCE, 2004, 13 (01) : 145 - 154
  • [7] Structural requirements for catalysis, expression, and dimerization in the CD26/DPIV gene family
    Ajami, K
    Abbott, CA
    Obradovic, M
    Gysbers, V
    Kähne, T
    McCaughan, GW
    Gorrell, MD
    [J]. BIOCHEMISTRY, 2003, 42 (03) : 694 - 701
  • [8] The role of TIMPs in regulation of extracellular matrix proteolysis
    Arpino, Valerie
    Brock, Michael
    Gill, Sean E.
    [J]. MATRIX BIOLOGY, 2015, 44-46 : 247 - 254
  • [9] Molecular proximity of seprase and the urokinase-type plasminogen activator receptor on malignant melanoma cell membranes:: dependence on β1 integrins and the cytoskeleton
    Artym, VV
    Kindzelskii, AL
    Chen, WT
    Petty, HR
    [J]. CARCINOGENESIS, 2002, 23 (10) : 1593 - 1601
  • [10] Acute Ischemic Stroke Severity, Progression, and Outcome Relate to Changes in Dipeptidyl Peptidase IV and Fibroblast Activation Protein Activity
    Baerts, Lesley
    Brouns, Raf
    Kehoe, Kaat
    Verkerk, Robert
    Engelborghs, Sebastiaan
    De Deyn, Peter Paul
    Hendriks, Dirk
    De Meester, Ingrid
    [J]. TRANSLATIONAL STROKE RESEARCH, 2017, 8 (02) : 157 - 164
12345678910