Cervical Lymph Node Metastasis in High-Grade Transformation of Head and Neck Adenoid Cystic Carcinoma: A Collective International Review

被引：51

作者：

Hellquist, Henrik ^{[1
]}

Skalova, Alena ^{[2
]}

Barnes, Leon ^{[3
]}

Cardesa, Antonio ^{[4
]}

Thompson, Lester D. R. ^{[5
]}

Triantafyllou, Asterios ^{[6
,7
]}

Williams, Michelle D. ^{[8
]}

Devaney, Kenneth O. ^{[9
]}

Gnepp, Douglas R. ^{[10
,11
]}

Bishop, Justin A. ^{[12
,13
]}

Wenig, Bruce M. ^{[14
]}

Suarez, Carlos ^{[15
,16
]}

Rodrigo, Juan P. ^{[16
,17
]}

Coca-Pelaz, Andres ^{[17
]}

Strojan, Primoz ^{[18
]}

Shah, Jatin P. ^{[19
]}

Hamoir, Marc ^{[20
,21
]}

Bradley, Patrick J. ^{[22
,23
]}

Silver, Carl E. ^{[24
,25
]}

Slootweg, Pieter J. ^{[26
]}

Vander Poorten, Vincent ^{[23
,27
,28
]}

Teymoortash, Afshin ^{[29
]}

Medina, Jesus E. ^{[30
]}

Robbins, K. Thomas ^{[31
]}

Pitman, Karen T. ^{[32
]}

Kowalski, Luiz P. ^{[33
]}

de Bree, Remco ^{[34
]}

Mendenhall, William M. ^{[35
]}

Eloy, Jean Anderson ^{[36
]}

Takes, Robert P. ^{[37
]}

Rinaldo, Alessandra ^{[38
]}

Ferlito, Alfio ^{[38
,39
]}

机构：

[1] Univ Algarve, Dept Biomed Sci & Med, Faro, Portugal

[2] Charles Univ Prague, Fac Med Plzen, Dept Pathol, Plzen, Czech Republic

[3] Univ Pittsburgh, Sch Med, Dept Pathol, Pittsburgh, PA USA

[4] Univ Barcelona, Hosp Clin, Dept Anat Pathol, Barcelona, Spain

[5] So Calif Permanente Med Grp, Woodland Hills, CA USA

[6] Univ Liverpool, Sch Dent, Oral & Maxillofacial Pathol, Liverpool, Merseyside, England

[7] Liverpool Clin Labs, Cellular Pathol, Liverpool, Merseyside, England

[8] Univ Texas MD Anderson Canc Ctr, Dept Pathol, Houston, TX 77030 USA

[9] Allegiance Hlth, Dept Pathol, Jackson, MI USA

[10] Univ Pathologists, Providence, RI USA

[11] Univ Pathologists, Fall River, MA USA

[12] Johns Hopkins Med Inst, Dept Pathol, Baltimore, MD 21205 USA

[13] Johns Hopkins Med Inst, Dept Otolaryngol Head & Neck Surg, Baltimore, MD 21205 USA

[14] Beth Israel Deaconess Med Ctr, Dept Pathol, New York, NY 10003 USA

[15] Fdn Invest & Innovac Biosanitaria Principado Astu, Oviedo, Spain

[16] Univ Oviedo, Inst Univ Oncol Principado Asturias, Oviedo, Spain

[17] Hosp Univ Cent Asturias, Dept Otolaryngol, Oviedo, Spain

[18] Inst Oncol, Dept Radiat Oncol, Ljubljana, Slovenia

[19] Mem Sloan Kettering Canc Ctr, Head & Neck Surg, 1275 York Ave, New York, NY 10021 USA

[20] St Luc Univ Hosp, Dept Head & Neck Surg, Head & Neck Oncol Program, Brussels, Belgium

[21] King Albert II Canc Inst, Brussels, Belgium

[22] Univ Nottingham Hosp, Queens Med Ctr Campus, Dept Otolaryngol Head & Neck Surg, Nottingham NG7 2UH, England

[23] European Salivary Gland Soc, Geneva, Switzerland

[24] Montefiore Med Ctr, Albert Einstein Coll Med, Dept Surg, Bronx, NY 10467 USA

[25] Albert Einstein Coll Med, Montefiore Med Ctr, Dept Otolaryngol Head & Neck Surg, Bronx, NY 10467 USA

[26] Radboud Univ Nijmegen, Med Ctr, Dept Pathol, NL-6525 ED Nijmegen, Netherlands

[27] Katholieke Univ Leuven, Univ Hosp Leuven, Otorhinolaryngol Head & Neck Surg, Leuven, Belgium

[28] Katholieke Univ Leuven, Univ Hosp Leuven, Dept Oncol, Sect Head & Neck Oncol, Leuven, Belgium

[29] Univ Marburg, Dept Otolaryngol Head & Neck Surg, Marburg, Germany

[30] Univ Oklahoma, Hlth Sci Ctr, Dept Otorhinolaryngol, Oklahoma City, OK USA

[31] So Illinois Univ, Sch Med, Div Otolaryngol Head & Neck Surg, Springfield, IL USA

[32] Banner MD Anderson Canc Ctr, Dept Surg, Gilbert, AZ USA

[33] AC Camargo Canc Ctr, Dept Head & Neck Surg & Otorhinolaryngol, Sao Paulo, Brazil

[34] Univ Med Ctr Utrecht, UMC Utrecht Canc Ctr, Dept Head & Neck Surg Oncol, Utrecht, Netherlands

[35] Univ Florida, Dept Radiat Oncol, Gainesville, FL USA

[36] Rutgers New Jersey Med Sch, Neurol Inst New Jersey, Dept Otolaryngol Head & Neck Surg, Newark, NJ USA

[37] Radboud Univ Nijmegen, Med Ctr, Dept Otolaryngol Head & Neck Surg, NL-6525 ED Nijmegen, Netherlands

[38] Univ Udine, Sch Med, I-33100 Udine, Italy

[39] Coordinator Int Head & Neck Sci Grp, Padua, Italy

来源：

ADVANCES IN THERAPY | 2016年 / 33卷 / 03期

关键词：

Adenoid cystic carcinoma; Dedifferentiation; Fatal outcome; Local recurrence; High-grade transformation; Lymphatic metastasis; Neck dissection; Neoplasm recurrence; Salivary glands; EPITHELIAL-MYOEPITHELIAL CARCINOMA; ACINIC CELL-CARCINOMA; ANALOG SECRETORY CARCINOMA; SALIVARY-GLANDS; HISTOLOGIC TRANSFORMATION; MUCOEPIDERMOID CARCINOMA; PAROTID-GLAND; DEDIFFERENTIATION; ADENOCARCINOMA; EXPRESSION;

D O I：

10.1007/s12325-016-0298-5

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Adenoid cystic carcinoma (AdCC) is among the most common malignant tumors of the salivary glands. It is characterized by a prolonged clinical course, with frequent local recurrences, late onset of metastases and fatal outcome. High-grade transformation (HGT) is an uncommon phenomenon among salivary carcinomas and is associated with increased tumor aggressiveness. In AdCC with high-grade transformation (AdCC-HGT), the clinical course deviates from the natural history of AdCC. It tends to be accelerated, with a high propensity for lymph node metastasis. In order to shed light on this rare event and, in particular, on treatment implications, we undertook this review: searching for all published cases of AdCC-HGT. We conclude that it is mandatory to perform elective neck dissection in patients with AdCC-HGT, due to the high risk of lymph node metastases associated with transformation.

引用

页码：357 / 368

页数：12

共 51 条

[1] High-grade carcinoma component in epithelial-myoepithelial carcinoma of salivary glands clinicopathological, immunohistochemical and flow-cytometric study of three cases [J].