The inositol polyphosphate 5-phosphatases: traffic controllers, waistline watchers and tumour suppressors?

被引：43

作者：

Astle, Megan V. ^{[1
]}

Horan, Kristy A. ^{[1
]}

Ooms, Lisa M. ^{[1
]}

Mitchell, Christina A. ^{[1
]}

机构：

[1] Monash Univ, Dept Biochem & Mol Biol, Clayton, Vic 3800, Australia

来源：

CELL BIOLOGY OF INOSITOL LIPIDS AND PHOSPHATES | 2007年 / 74卷

关键词：

D O I：

10.1042/BSS2007c15

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Phosphoinositide signals regulate cell proliferation, differentiation, cytoskeletal rearrangement and intracellular trafficking. Hydrolysis of Ptdlns(4,5)p(2) and Ptdlns(3,4,5)P-3, by inositol polyphosphate 5-phosphatases regulates synaptic vesicle recycling (synaptojanin-1), hematopoletic cell function [SHIP1(SH2-containing inositol polyphosphate 5-phosphatase-1)], renal cell function [OCRL (oculocerebrorenal syndrome of Lowe)] and insulin signalling (SHIP2). We present here a detailed review of the characteristics of the ten mammalian 5-phosphatases. Knockout mouse phenotypes and underexpression studies are associated with significant phenotypic changes, indicating non-redundant roles, despite, in many cases, overlapping substrate specificity and tissue expression. The extraordinary complexity in the control of phosphoinositide signalling continues to be revealed.

引用

页码：161 / 181

页数：21

共 155 条

[1] The inositol phosphatase SHIP-2 down-regulates FcγR-mediated phagocytosis in murine macrophages independently of SHIP-1 [J].

Ai, J ;

Maturu, A ;

Johnson, W ;

Wang, YJ ;

Marsh, CB ;

Tridandapani, S .

BLOOD, 2006, 107 (02) :813-820

[2] Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase B alpha [J].

Alessi, DR ;

James, SR ;

Downes, CP ;

Holmes, AB ;

Gaffney, PRJ ;

Reese, CB ;

Cohen, P .

CURRENT BIOLOGY, 1997, 7 (04) :261-269

[3] Essential role for the C-terminal noncatalytic region of SHIP in FcγRIIB1-mediated inhibitory signaling [J].

Aman, MJ ;

Walk, SF ;

March, ME ;

Su, HP ;

Carver, DJ ;

Ravichandran, KS .

MOLECULAR AND CELLULAR BIOLOGY, 2000, 20 (10) :3576-3589

[4] Pharbin, a novel inositol polyphosphate 5-phosphatase, induces dendritic appearances in fibroblasts [J].

Asano, T ;

Mochizuki, Y ;

Matsumoto, K ;

Takenawa, T ;

Endo, T .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1999, 261 (01) :188-195

[5] Recent advances in the regulation of the TOR pathway by insulin and nutrients [J].

Avruch, J ;

Lin, YS ;

Long, XM ;

Murthy, S ;

Ortiz-Vega, S .

CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE, 2005, 8 (01) :67-72

[6] The termination of PI3K signalling by SHIP1 and SHIP2 inositol 5-phosphatases [J].

Backers, K ;

Blero, D ;

Paternotte, N ;

Zhang, J ;

Erneux, C .

ADVANCES IN ENZYME REGULATION, VOL 43, 2003, 43 :15-28

[7] Differential regulation of B cell development, activation, and death by the Src homology 2 domain-containing 5′ inositol phosphatase (SHIP) [J].

Brauweiler, A ;

Tamir, I ;

Dal Porto, J ;

Benschop, RJ ;

Helgason, CD ;

Humphries, RK ;

Freed, JH ;

Cambier, JC .

JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 191 (09) :1545-1554

[8] Autonomous SHIP-dependent FcγR signaling in pre-B cells leads to inhibition of cell migration and induction of cell death [J].

Brauweiler, AM ;

Cambier, JC .

IMMUNOLOGY LETTERS, 2004, 92 (1-2) :75-81

[9] Caenorhabditis elegans inositol 5-phosphatase homolog negatively regulates inositol 1,4,5-triphosphate signaling in ovulation [J].

Bui, YK ;

Sternberg, PW .

MOLECULAR BIOLOGY OF THE CELL, 2002, 13 (05) :1641-1651

[10] The phosphoinositide 3-kinase pathway [J].

Cantley, LC .

SCIENCE, 2002, 296 (5573) :1655-1657

← 1 2 3 4 5 6 7 8 9 10 →