The inositol polyphosphate 5-phosphatases: traffic controllers, waistline watchers and tumour suppressors?

被引：43
作者：
Astle, Megan V. [1 ]
Horan, Kristy A. [1 ]
Ooms, Lisa M. [1 ]
Mitchell, Christina A. [1 ]
机构：
[1] Monash Univ, Dept Biochem & Mol Biol, Clayton, Vic 3800, Australia
来源：
CELL BIOLOGY OF INOSITOL LIPIDS AND PHOSPHATES | 2007年 / 74卷
关键词：
D O I：
10.1042/BSS2007c15
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Phosphoinositide signals regulate cell proliferation, differentiation, cytoskeletal rearrangement and intracellular trafficking. Hydrolysis of Ptdlns(4,5)p(2) and Ptdlns(3,4,5)P-3, by inositol polyphosphate 5-phosphatases regulates synaptic vesicle recycling (synaptojanin-1), hematopoletic cell function [SHIP1(SH2-containing inositol polyphosphate 5-phosphatase-1)], renal cell function [OCRL (oculocerebrorenal syndrome of Lowe)] and insulin signalling (SHIP2). We present here a detailed review of the characteristics of the ten mammalian 5-phosphatases. Knockout mouse phenotypes and underexpression studies are associated with significant phenotypic changes, indicating non-redundant roles, despite, in many cases, overlapping substrate specificity and tissue expression. The extraordinary complexity in the control of phosphoinositide signalling continues to be revealed.
引用
收藏
页码：161 / 181
页数：21
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