Photocatalyst-Free, Visible-Light-Mediated C(sp3)-H Arylation of Amides via a Solvent-Caged EDA Complex

被引：39

作者：

Kaur, Jaspreet ^{[1
]}

Shahin, Ahmed ^{[1
,2
]}

Barham, Joshua P. ^{[1
]}

机构：

[1] Univ Regensburg, Fak Chem & Pharm, D-93040 Regensburg, Germany

[2] Benha Univ, Fac Sci, Chem Dept, Banha 13518, Egypt

来源：

ORGANIC LETTERS | 2021年 / 23卷 / 06期

关键词：

D O I：

10.1021/acs.orglett.1c00132

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A photocatalyst-free and mild visible light photochemical procedure for C(sp(3))-H arylation of amides is described. The reaction proceeds via an electron donor-acceptor (EDA) complex between an electron-rich arene substrate and electron-poor persulfate oxidant. C(sp(3))-H arylation of the amide occurs selectively with the most electron-rich arene of the substrate. Mechanistic studies corroborate the reaction taking place in a solvent cage holding components in a close proximity.

引用

页码：2002 / 2006

页数：5

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