Migration of Founder Epithelial Cells Drives Proper Molar Tooth Positioning and Morphogenesis

被引：38

作者：

Prochazka, Jan ^{[1
,2
,3
]}

Prochazkova, Michaela ^{[1
,2
,3
]}

Du, Wen ^{[1
,2
,4
]}

Spoutil, Frantisek ^{[3
]}

Tureckova, Jolana ^{[3
]}

Hoch, Renee ^{[5
]}

Shimogori, Tomomi ^{[6
]}

Sedlacek, Radislav ^{[3
]}

Rubenstein, John L. ^{[5
]}

Wittmann, Torsten ^{[7
]}

Klein, Ophir D. ^{[1
,2
,8
,9
]}

机构：

[1] Univ Calif San Francisco, Dept Orofacial Sci, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Program Craniofacial Biol, San Francisco, CA 94143 USA

[3] Inst Mol Genet ASCR, Lab Transgen Models Dis, Vvi, Prague 14220 4, Czech Republic

[4] Sichuan Univ, West China Hosp Stomatol, State Key Lab Oral Dis, Chengdu 610041, Sichuan, Peoples R China

[5] Univ Calif San Francisco, Nina Ireland Lab Dev Neurobiol, Dept Psychiat, San Francisco, CA 94143 USA

[6] RIKEN, Brain Sci Inst, Lab Mol Mech Thalamus Dev, Wako, Saitama 3510198, Japan

[7] Univ Calif San Francisco, Dept Cell & Tissue Biol, San Francisco, CA 94143 USA

[8] Univ Calif San Francisco, Dept Pediat, San Francisco, CA 94143 USA

[9] Univ Calif San Francisco, Inst Human Genet, San Francisco, CA 94143 USA

来源：

DEVELOPMENTAL CELL | 2015年 / 35卷 / 06期

关键词：

LATERAL-LINE; MAMMALIAN TOOTH; FGF; ZEBRAFISH; PATTERN; CANCER; PROLIFERATION; INHIBITION; EXPRESSION; DENTITION;

D O I：

10.1016/j.devcel.2015.11.025

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The proper positioning of organs during development is essential, yet little is known about the regulation of this process in mammals. Using murine tooth development as a model, we have found that cell migration plays a central role in positioning of the organ primordium. By combining lineage tracing, genetic cell ablation, and confocal live imaging, we identified a migratory population of Fgf8-expressing epithelial cells in the embryonic mandible. These Fgf8-expressing progenitors furnish the epithelial cells required for tooth development, and the progenitor population migrates toward a Shh-expressing region in the mandible, where the tooth placode will initiate. Inhibition of Fgf and Shh signaling disrupted the oriented migration of cells, leading to a failure of tooth development. These results demonstrate the importance of intraepithelial cell migration in proper positioning of an initiating organ.

引用

页码：713 / 724

页数：12

共 5 条

[1] Epithelial stratification and placode invagination are separable functions in early morphogenesis of the molar tooth
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