Chemical biology tools for imaging-based analysis of organelle membranes and lipids

被引：4
|
作者：
Tamura, Tomonori [1 ]
Hamachi, Itaru [1 ,2 ]
机构：
[1] Kyoto Univ, Grad Sch Engn, Dept Synthet Chem & Biol Chem, Nishikyo, Kyoto 6158510, Japan
[2] Japan Sci & Technol Agcy JST, ERATO, 5 Sanbancho, Tokyo, Tokyo 1020075, Japan
来源：
CURRENT OPINION IN CHEMICAL BIOLOGY | 2022年 / 70卷
基金：
日本科学技术振兴机构; 日本学术振兴会;
关键词：
Organelle membrane; Imaging; Lipid probe; FLUORESCENT-PROBES; ORGANIZATION; DYNAMICS; TENSION; CELLS;
D O I：
10.1016/j.cbpa.2022.102182
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Membrane biology studies have revealed that in addition to providing structural support for compartment formation and membrane protein function, subcellular biomembranes are also critically involved in many biological events. To facilitate our understanding of the functions, biophysical properties and structural dynamics of organelle membranes, various exciting chemical biology tools have recently emerged. This short review aims to describe the latest molecular probes for organelle membrane studies. In particular, we will feature chemical strategies to visualize and quantitatively analyze the dynamic propeties of organelle membranes and lipids and discuss current limitations and potential future directions of this challenging research area.
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页数：9
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