A tumor microenvironment model coupled with a mass spectrometry system to probe the metabolism of drug-loaded nanoparticles

被引：18

作者：

Lin, Ling ^{[1
,2
]}

Zheng, Yajing ^{[1
,3
]}

Wu, Zengnan ^{[1
,3
]}

Zhang, Wei ^{[1
,2
]}

Lin, Jin-Ming ^{[2
]}

机构：

[1] Natl Ctr Nanosci & Technol, CAS Ctr Excellence Nanosci, CAS Key Lab Standardizat & Measurement Nanotechno, Beijing 100190, Peoples R China

[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

[3] Tsinghua Univ, Beijing Key Lab Microanalyt Methods & Instrumenta, MOE Key Lab Bioorgan Phosphorus Chem & Chem Biol, Dept Chem, Beijing 100084, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2019年 / 55卷 / 69期

基金：

中国国家自然科学基金;

关键词：

MICROFLUIDIC DEVICE; PRINCIPLES;

D O I：

10.1039/c9cc04628c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This study describes a novel integrated microfluidic platform with microvessel network channels which are connected to an electrospray ionization-mass spectrometer (ESI-MS), allowing real-time probing of nanoparticle (NP) drug delivery in vascular niche around tumors and understanding the drug delivery efficacy in a realistic tumor microenvironment.

引用

页码：10218 / 10221

页数：4

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