A tumor microenvironment model coupled with a mass spectrometry system to probe the metabolism of drug-loaded nanoparticles

被引：18
|
作者：
Lin, Ling [1 ,2 ]
Zheng, Yajing [1 ,3 ]
Wu, Zengnan [1 ,3 ]
Zhang, Wei [1 ,2 ]
Lin, Jin-Ming [2 ]
机构：
[1] Natl Ctr Nanosci & Technol, CAS Ctr Excellence Nanosci, CAS Key Lab Standardizat & Measurement Nanotechno, Beijing 100190, Peoples R China
[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
[3] Tsinghua Univ, Beijing Key Lab Microanalyt Methods & Instrumenta, MOE Key Lab Bioorgan Phosphorus Chem & Chem Biol, Dept Chem, Beijing 100084, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2019年 / 55卷 / 69期
基金：
中国国家自然科学基金;
关键词：
MICROFLUIDIC DEVICE; PRINCIPLES;
D O I：
10.1039/c9cc04628c
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
This study describes a novel integrated microfluidic platform with microvessel network channels which are connected to an electrospray ionization-mass spectrometer (ESI-MS), allowing real-time probing of nanoparticle (NP) drug delivery in vascular niche around tumors and understanding the drug delivery efficacy in a realistic tumor microenvironment.
引用
收藏
页码：10218 / 10221
页数：4
相关论文
共 50 条
  • [31] Drug-loaded microbubble delivery system to enhance PD-L1 blockade immunotherapy with remodeling immune microenvironment
    Jun Zheng
    Ju Huang
    Liang Zhang
    Mengna Wang
    Lihong Xu
    Xiaoyun Dou
    Xiaojing Leng
    Mingxiao Fang
    Yang Sun
    Zhigang Wang
    Biomaterials Research, 27
  • [32] Construction of multi-functional delivery system: transferrin mediated tat and drug-loaded magnetic nanoparticles
    YAO PENG ZHAO Aijie KANG Chunsheng Yuan Xubo CHANG Jin PU Peiyu Institute of Nanobiotechnology School of Materials Science and Engineering Tianjin University Tianjin PRChina General Hospital Tianjin Medical University Tianjin PRChina
    中国医学工程, 2005, (02) : 113 - 120
  • [33] Drug-loaded microbubble delivery system to enhance PD-L1 blockade immunotherapy with remodeling immune microenvironment
    Zheng, Jun
    Huang, Ju
    Zhang, Liang
    Wang, Mengna
    Xu, Lihong
    Dou, Xiaoyun
    Leng, Xiaojing
    Fang, Mingxiao
    Sun, Yang
    Wang, Zhigang
    BIOMATERIALS RESEARCH, 2023, 27 (01)
  • [34] Development and characterization of a small electromembrane extraction probe coupled with mass spectrometry for real-time and online monitoring of in vitro drug metabolism
    Dugstad, Helene Bonkerud
    Petersen, Nickolaj Jacob
    Jensen, Henrik
    Gabel-Jensen, Charlotte
    Hansen, Steen Honore
    Pedersen-Bjergaard, Stig
    ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2014, 406 (02) : 421 - 429
  • [35] Development and characterization of a small electromembrane extraction probe coupled with mass spectrometry for real-time and online monitoring of in vitro drug metabolism
    Helene Bonkerud Dugstad
    Nickolaj Jacob Petersen
    Henrik Jensen
    Charlotte Gabel-Jensen
    Steen Honoré Hansen
    Stig Pedersen-Bjergaard
    Analytical and Bioanalytical Chemistry, 2014, 406 : 421 - 429
  • [36] Multi-responsive photothermal-chemotherapy with drug-loaded melanin-like nanoparticles for synergetic tumor ablation
    Wang, Xinyu
    Zhang, Jishen
    Wang, Yitong
    Wang, Changping
    Xiao, Jianru
    Zhang, Qiang
    Cheng, Yiyun
    BIOMATERIALS, 2016, 81 : 114 - 124
  • [37] Peptide-Functionalized and Drug-Loaded Tomato Bushy Stunt Virus Nanoparticles Counteract Tumor Growth in a Mouse Model of Shh-Dependent Medulloblastoma
    Marchetti, Luca
    Novelli, Flavia
    Tanno, Barbara
    Leonardi, Simona
    Hizam, Veronica Mohamed
    Arcangeli, Caterina
    Santi, Luca
    Baschieri, Selene
    Lico, Chiara
    Mancuso, Mariateresa
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (10)
  • [38] Engineering of hybrid anticancer drug-loaded polymeric nanoparticles delivery system for the treatment and care of lung cancer therapy
    Zhao, Yang
    Liu, Kefeng
    Li, Jie
    Liao, Juan
    Ma, Li
    DRUG DELIVERY, 2021, 28 (01) : 1539 - 1547
  • [39] DR5-targeted, chemotherapeutic drug-loaded nanoparticles induce apoptosis and tumor regression in pancreatic cancer in vivo models
    Johnston, Michael C.
    Nicoll, Julie A.
    Redmond, Kelly M.
    Smyth, Peter
    Greene, Michelle K.
    McDaid, William J.
    Chan, Darren K. W.
    Crawford, N.
    Stott, Katie J.
    Fox, Jennifer P.
    Straubinger, Ninfa L.
    Roche, Sandra
    Clynes, Martin
    Straubinger, Robert M.
    Longley, Daniel B.
    Scott, Christopher J.
    JOURNAL OF CONTROLLED RELEASE, 2020, 324 : 610 - 619
  • [40] Acid-responsive drug-loaded copper phosphate nanoparticles for tumor cell therapy through synergistic apoptosis and ferroptosis strategy
    Zhao, Sheng
    He, Liang
    Sun, Yihao
    Xu, Ting
    Chen, Chunmei
    Ouyang, Yi
    Chen, Yan
    Tan, Yixin
    Zhou, Benqing
    Liu, Hui
    JOURNAL OF NANOPARTICLE RESEARCH, 2023, 25 (01)
12345