The design plan of kinesin motors

被引：379
作者：
Vale, RD
Fletterick, RJ
机构：
[1] Univ Calif San Francisco, Howard Hughes Med Inst, San Francisco, CA 94143 USA
[2] Univ Calif San Francisco, Dept Pharmacol, San Francisco, CA 94143 USA
[3] Univ Calif San Francisco, Dept Biochem, San Francisco, CA 94143 USA
来源：
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY | 1997年 / 13卷
关键词：
kinesin; microtubules; motor proteins; cytoskeleton; protein structure;
D O I：
10.1146/annurev.cellbio.13.1.745
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The kinesin superfamily comprises a large and structurally diverse group of microtubule-based motor proteins that produce a variety of force-generating activities within cells. This review addresses how the structures of kinesin proteins provide clues as to their biological functions and motile properties. We discuss structural features common to all kinesin motors, as well as specialized features that enable subfamilies of related motors to carry out specialized activities. We also discuss how the kinesin motor domain uses chemical energy from ATP hydrolysis to move along microtubules.
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页码：745 / 777
页数：33
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