Clinical characterization of autoimmune LGI1 antibody limbic encephalitis

被引：45

作者：

Gao, Lehong ^{[1
]}

Liu, Aihua ^{[1
]}

Zhan, Shuqin ^{[1
]}

Wang, Li ^{[1
]}

Li, Liping ^{[1
]}

Guan, Le ^{[2
]}

Zhao, Xin ^{[1
]}

Zhang, Xiating ^{[1
]}

Wang, Yuping ^{[1
]}

机构：

[1] Capital Med Univ, Beijing Key Lab Neuromodulat, Xuanwu Hosp, Dept Neurol, Beijing, Peoples R China

[2] Capital Med Univ, Xuanwu Hosp, Dept Nucl Med, Beijing, Peoples R China

来源：

EPILEPSY & BEHAVIOR | 2016年 / 56卷

关键词：

Autoimmune encephalitis; LGI1; Limbic encephalitis; FACIOBRACHIAL DYSTONIC SEIZURES; IMMUNOTHERAPY; EPILEPSY; MANIFESTATIONS; AUTOANTIBODIES; SLEEP; GENE; FORM; RICH;

D O I：

10.1016/j.yebeh.2015.12.041

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Objective: Autoimmune encephalitis associated with antibodies to leucine-rich glioma inactivated 1 (LGI1) has recently been identified and is characterized by an acute to subacute onset of cognitive impairment and convulsion, faciobrachial dystonic seizures (FBDSs), and psychiatric disturbances. This study analyzed the clinical characteristics and outcomes of 10 patients with LGI1 antibody encephalitis in order to further understand this disease and to improve its therapeutic strategies. Methods: Between January 2013 and March 2015, we identified 10 patients with LGI1 antibody encephalitis. We retrospectively analyzed the clinical details, laboratory results, electrophysiological and imaging findings, and the treatment outcomes. Results: All patients tested had LGI1 antibodies. Immunotherapy was effective in all patients. Seizures in patients with FBDS showed a poor response to antiepileptic drugs. Two patients examined by magnetoencephalogram (MEG) during the acute disease phase showed a small quantity of spike-wave dipoles in the temporal lobe close to the lateral fissure and insular lobe. Conclusion: Patients with LGI1 antibody encephalitis responded well to immunotherapy. We speculate that FBDS is likely a form of insular epilepsy. (C) 2016 Elsevier Inc. All rights reserved.

引用

页码：165 / 169

页数：5

共 29 条

[1] TONIC SEIZURES: A DIAGNOSTIC CLUE OF ANTI-LGI1 ENCEPHALITIS? [J].