Progesterone, progestins and the endometrium in perimenopause and in menopausal hormone therapy

被引：22
作者：
Gompel, A. [1 ]
机构：
[1] Univ Paris 05, Hop Univ Port Royal Cochin, Unite Gynecol Endocrinienne, F-75014 Paris, France
来源：
CLIMACTERIC | 2018年 / 21卷 / 04期
关键词：
Menopause hormone therapy; conjugated estrogens; transdermal estradiol; micronized progesterone; levonorgestrel-releasing intrauterine device; endometrial cancer; hyperplasia; obesity; HEALTHY POSTMENOPAUSAL WOMEN; INTRAUTERINE SYSTEM; MICRONIZED PROGESTERONE; REPLACEMENT THERAPY; BREAST-CANCER; RANDOMIZED-TRIAL; RISK; HYPERPLASIA; ESTRADIOL; BIOCHEMISTRY;
D O I：
10.1080/13697137.2018.1446932
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
It is well established that unopposed estrogen for hormone therapy in postmenopausal women (MHT) induces a dose-related stimulation of the endometrium associated with an increased risk of hyperplasia and endometrial cancer. Progesterone acts physiologically to counteract the proliferative effects of estradiol during the menstrual cycle. In MHT, progestogens protect the endometrium against the proliferative effects of estrogens in women with a uterus. Recent data suggest that, whereas micronized progesterone is apparently safer for the breast, it could be less efficient than synthetic progestin on the endometrium. An update on progestogen and endometrial safety in MHT is the subject of this review.
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收藏
页码：321 / 325
页数：5
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