IRF4 is modulated by CD40L and by apoptotic and anti-proliferative signals in Hodgkin lymphoma

被引：15

作者：

Aldinucci, Donatella ^{[1
]}

Rapana', Barbara ^{[1
]}

Olivo, Karin ^{[1
]}

Lorenzon, Debora ^{[2
]}

Gloghini, Annunziata ^{[3
]}

Colombatti, Alfonso ^{[1
,4
,5
]}

Carbone, Antonino ^{[3
]}

机构：

[1] Natl Canc Inst, IRCCS, Ctr Riferimento Oncol, Aviano, PN, Italy

[2] Treviso Reg Hosp, Cord Blood Bank, Cell Culture Lab, I-31100 Treviso, Italy

[3] Natl Canc Inst, Fdn IRCCS, Dept Pathol & Lab Med, I-20133 Milan, Italy

[4] Univ Udine, Dept Biomed Sci & Technol, I-33100 Udine, Italy

[5] Univ Udine, dMATI Micrograv Ageing Training Immobil Excellenc, I-33100 Udine, Italy

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2010年 / 148卷 / 01期

关键词：

Hodgkin lymphoma; IRF4; MUM1; CD40; CD95; FAS; chemotherapy; REED-STERNBERG CELLS; CENTER B-CELLS; REGULATORY FACTOR-4; DOWN-REGULATION; EXPRESSION; MUM1/IRF4; DIFFERENTIATION; DISEASE; SUBSET; LINES;

D O I：

10.1111/j.1365-2141.2009.07945.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

P>The effects of proliferative, apoptotic and anti-proliferative stimuli on interferon regulatory factor 4 (IRF4) expression by Reed-Sternberg (RS) cells were analysed using a panel of Hodgkin lymphoma (HL)-derived cell lines. IRF4 expressed by HL cells was consistently upregulated after CD40 engagement; IRF4 was downregulated by agonistic anti-CD95 antibodies in the FAS-sensitive HDLM-2 cells and after treatment with Adriamycin and Dacarbazine, two chemotherapic agents commonly used for HL treatment. These results demonstrated, for the first time, that IRF4 was up-modulated by CD40 engagement, and down-modulated by apoptotic and anti-proliferative signals, suggesting an involvement of IRF4 also in HL pathobiology.

引用

收藏

页码：115 / 118

页数：4

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